Journal ArticleDOI
Nitroalkenes in the Ni(II) Catalyzed Asymmetric Michael Addition. Convenient Route to the Key Intermediate of Brivaracetam
Alexander N. Reznikov,Leonid E. Kapranov,Valentina V. Ivankina,Anastasiya E. Sibiryakova,Victor B. Rybakov,Yuri N. Klimochkin +5 more
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This article is published in Helvetica Chimica Acta.The article was published on 2018-12-01. It has received 13 citations till now. The article focuses on the topics: Michael reaction.read more
Citations
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Journal ArticleDOI
Straightforward Access to High-Performance Organometallic Catalysts by Fluoride Activation: Proof of Principle on Asymmetric Cyanation, Asymmetric Michael Addition, CO2 Addition to Epoxide, and Reductive Alkylation of Amines by Tetrahydrofuran
Alexey A. Tsygankov,Denis Chusov +1 more
TL;DR: In this paper, the authors demonstrate that well-known transition metal catalysts can be transformed into high-performance versions by the simple use of a fluoride anion source, and demonstrate that in situ fluoride-activated catalysts are high performance.
Journal ArticleDOI
Synthetic Approaches toward the Synthesis of Brivaracetam: An Antiepileptic Drug
TL;DR: In this article , a review encapsulates the reported literature on synthetic strategies for brivaracetam, which will assist medicinal chemists in the further progress of its synthesis, as compared to conventional drug levetiracetam and piracetam.
Journal ArticleDOI
Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni(II)-catalyzed asymmetric Michael reaction of β-ketosulfones.
Alexander N. Reznikov,Anastasiya E. Sibiryakova,M. R. Baimuratov,Eugene Golovin,Victor B. Rybakov,Yuri N. Klimochkin +5 more
TL;DR: It has been established that the catalytic Michael reaction itself was carried out with high diastereoselectivity, but the Michael adducts may epimerize at the C-2 position at a significant rate.
Journal ArticleDOI
Chemoenzymatic Stereoselective Synthesis of Substituted γ- or δ-lactams with Two Chiral Centers via Transaminase-catalysed Dynamic Kinetic Resolution
TL;DR: This study represents a promising approach to the biocatalytic synthesis of important γ‐ and δ‐lactams with two chiral centers by a dynamic kinetic resolution strategy.
Journal ArticleDOI
DFT insight into mechanism of the Ni(II)-catalyzed enantioselective Michael addition: A combined computational and experimental study
TL;DR: In this paper, a mechanistic pathway that proceeds via formation of enolate, intramolecular nucleophilic attack on coordinated nitroolefin and protonation of resulting nitronate complex was investigated.
References
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Journal ArticleDOI
Corrigendum to “Palladium-mediated reductive Mizoroki–Heck cyclization strategy for the regioselective formation of dibenzoazocinone framework” [Tetrahedron Lett. 51 (2010) 3372]
Book ChapterDOI
The “Med Check”
TL;DR: Following-up psychopharmacology visits need to be long enough to allow for attention to the interpersonal relationship, such as transference, and the use of psychotherapeutic methods is helpful.
Related Papers (5)
Enantioselective nickel-catalyzed Michael additions of azaarylacetates and acetamides to nitroalkenes.
Charlene Fallan,Hon Wai Lam +1 more