Journal ArticleDOI
Nonspecific white matter degeneration following traumatic brain injury
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TLDR
Results demonstrate the diffuse nature of degeneration in TBI with more severe injury, and that quantified MR identified morphologic changes relate to neuropsychological outcome.Abstract:
Morphometric analysis of magnetic resonance (MR) scans in 88 traumatic brain injury (TBI) patients demonstrated significantly larger ventricle-to-brain ratios (VBR) and temporal horn volumes, and significantly smaller fornix-to-brain ratios (FBR) and corpus callosum (CC) area measurements, compared to 73 controls. Additionally, TBI patients were grouped according to Glasgow Coma Scale (GCS) for a within-TBI sample comparison so that severity of injury on brain morphology could be examined. The severe TBI group (GCS = 3–6) differed from the mild and moderate injury groups on measures of the internal capsule, VBR, temporal horn volume, and CC. In a separate analysis wherein the TBI subjects were grouped by degree of fornix atrophy, the group with the smallest fornix size demonstrated the lowest memory performance. Furthermore, anatomic measures correlated with severity of injury, and tests of memory and motor function. Results demonstrate the diffuse nature of degeneration in TBI with more severe injury, and that quantified MR identified morphologic changes relate to neuropsychological outcome. (JINS, 1995, 1, 17–28.)read more
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Diabetes mellitus and the risk of dementia The Rotterdam Study
Alewijn Ott,Ronald P. Stolk,F. van Harskamp,H. A. P. Pols,Albert Hofman,Monique M.B. Breteler +5 more
TL;DR: The diabetes attributable risk for dementia of 8.8% suggests that diabetes may have contributed to the clinical syndrome in a substantial proportion of all dementia patients.
Journal ArticleDOI
Axonal Pathology in Traumatic Brain Injury
TL;DR: The current understanding of DAI as a uniquely mechanical injury, its histopathological identification, and its acute and chronic pathogenesis following TBI are reviewed.
Journal ArticleDOI
Inflammation and white matter degeneration persist for years after a single traumatic brain injury
Victoria E. Johnson,Janice Stewart,Janice Stewart,Finn D. Begbie,John Q. Trojanowski,Douglas H. Smith,William Stewart,William Stewart +7 more
TL;DR: Findings may provide parallels for studying neurodegenerative disease, with traumatic brain injury patients serving as a model for longitudinal investigations, in particular with a view to identifying potential therapeutic interventions.
Journal ArticleDOI
A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury
Martha E. Shenton,Martha E. Shenton,Hesham M. Hamoda,Hesham M. Hamoda,Jason S. Schneiderman,Sylvain Bouix,Ofer Pasternak,Yogesh Rathi,M.-A. Vu,Maulik P. Purohit,Maulik P. Purohit,Maulik P. Purohit,Karl G. Helmer,Inga K. Koerte,Alexander P. Lin,Carl-Fredrik Westin,Ron Kikinis,Marek Kubicki,Robert S. Stern,Ross Zafonte +19 more
TL;DR: It is believed that the enhanced sensitivity of newer and more advanced neuroimaging techniques for identifying areas of brain damage in mTBI will be important for documenting the biological basis of postconcussive symptoms, which are likely associated with subtle brain alterations.
Journal ArticleDOI
Neuropsychology and clinical neuroscience of persistent post-concussive syndrome.
TL;DR: The focus of this review is on the current status of PPCS as a clinical entity from the perspective of recent advances in the biomechanical modeling of concussion in human and animal studies, particularly directed at a better understanding of the neuropathology associated with concussion.
References
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Book
Statistical Methods for Psychology
TL;DR: The Statistical Methods for Psychology as discussed by the authors survey statistical techniques commonly used in the behavioral and social sciences, especially psychology and education, and is suitable for either a one-term or a full-year course, and has been used successfully for both.
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The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
Ralph M. Reitan,Deborah Wolfson +1 more
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A Standardized Memory Scale for Clinical Use
TL;DR: In this article, a standardized memory scale for clinical use is presented. But it is not suitable for the task of clinical evaluation. The Journal of Psychology: Vol. 19, No. 1, No 1, pp. 87-95.
Journal ArticleDOI
Diffuse axonal injury and traumatic coma in the primate
Thomas A. Gennarelli,Lawrence E. Thibault,J H Adams,David I. Graham,C J Thompson,R. P. Marcincin +5 more
TL;DR: It is concluded that axonal damage produced by coronal head acceleration is a major cause of prolonged traumatic coma and its sequelae and is identical to that seen in severe head injury in humans.
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