Journal ArticleDOI
Novel therapies for childhood cancer and impact on puberty
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TLDR
Recognising reduced endocrine sequelae to lower intensity treatments and potential future toxicities of new treatments are both key for future long-term follow up strategies.About:
This article is published in Current Opinion in Endocrine and Metabolic Research.The article was published on 2020-10-01. It has received 3 citations till now. The article focuses on the topics: Cancer.read more
Citations
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Gonadal and Sexual Dysfunction in Childhood Cancer Survivors
Juyoung Yoon,Hyeon Jin Park,Jin Soo Chung,Sang-Hyun Hwang,Dong Ock Lee,Hye Young Shim,Byung Kiu Park +6 more
TL;DR: The childhood cancer survivors in this study showed a high prevalence of gonadal/sexual dysfunction; accordingly, proper strategies are needed to manage these complications.
Journal ArticleDOI
Long-Term Outcomes of Total Body Irradiation Plus Cyclophosphamide Versus Busulfan Plus Cyclophosphamide As Conditioning Regimen for Acute Lymphoblastic Leukemia: A Comparative Study
Ioanna Sakellari,Eleni Gavriilaki,Konstantinos Chatziioannou,Maria Papathanasiou,Despina Mallouri,Ioannis Batsis,Zoi Bousiou,Stella Bouziana,Varnavas Constantinou,Vassiliki Douka,Chrysa Apostolou,Anastasia Marvaki,Maria Kaliou,Michalis Iskas,Damianos Sotiropoulos,Evangelia Yannaki,Christos Smias,Vasilis Gianouzakos,Achilles Anagnostopoulos +18 more
TL;DR: In conclusion, high-dose TBI is feasible in younger patients providing better survival, and the choice between TBI- or Bu-conditioning regimens remains challenging.
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Journal ArticleDOI
Survivors of childhood and adolescent cancer: life-long risks and responsibilities
TL;DR: The burden of responsibility to understand the long-term morbidity and mortality that is associated with currently successful treatments must be borne by many, including the research and health care communities, survivor advocacy groups, and governmental and policy-making entities.
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Cancer immunotherapy - immune checkpoint blockade and associated endocrinopathies.
TL;DR: The current data regarding immune-related endocrinopathies, including hypophysitis, thyroid dysfunction and diabetes mellitus are described and the clinical management of these endocrineopathies is discussed within the context of the current understanding of the mechanisms of IRAEs.
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Ovarian Failure and Reproductive Outcomes After Childhood Cancer Treatment: Results From the Childhood Cancer Survivor Study
Daniel M. Green,Charles A. Sklar,John D. Boice,John J. Mulvihill,John Whitton,Marilyn Stovall,Yutaka Yasui +6 more
TL;DR: These studies demonstrated that women treated with pelvic irradiation and/or increasing alkylating agent doses were at risk for acute ovarian failure, premature menopause, and small-for-gestational-age offspring.
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Survivors of Childhood Cancer in the United States: Prevalence and Burden of Morbidity
Siobhan M. Phillips,Lynne Padgett,Wendy M. Leisenring,Kayla K. Stratton,Ken Bishop,Kevin R. Krull,Catherine M. Alfano,Todd M. Gibson,Janet S. de Moor,Danielle Blanch Hartigan,Gregory T. Armstrong,Leslie L. Robison,Julia H. Rowland,Kevin C. Oeffinger,Angela B. Mariotto +14 more
TL;DR: The Estimated prevalence of survivors of childhood cancer is increasing, as is the estimated prevalence of morbidity in those ≥5 years after diagnosis, and efforts to understand how to effectively decrease morbidity burden and incorporate effective care coordination and rehabilitation models to optimize longevity and well-being in this population should be a priority.
Journal ArticleDOI
Endocrine side effects induced by immune checkpoint inhibitors
Salvatore Maria Corsello,Agnese Barnabei,Paolo Marchetti,Liana De Vecchis,Roberto Salvatori,Francesco Torino +5 more
TL;DR: Hypophysitis has emerged as a distinctive side effect of CTLA4-blocking antibodies, establishing a new form of autoimmune pituitary disease in patients affected by advanced cutaneous melanoma.