Journal ArticleDOI
Nutritive and non-nutritive blood flow in canine skeletal muscle after partial microembolization.
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TLDR
Venous oxygen saturation increased despite decreasing total blood flow in the working muscle after microembolization, and the data indicate a shift of blood flow from nutritive to functionally non-nutritive channels.Abstract:
Partial microembolization of the previously dilated gastrocnemius muscle of the dog was performed by intra-arterial injection of latex microspheres (max. diameter 50 mum). No particles larger than 10 mum were recovered from the venous blood. Blood to tissue clearance of 4-amino-antipyrine was found to decrease after microembolization, and capillary transport coefficients were disproportionately lowered in comparison with the observed decrease of total blood flow. Venous oxygen saturation increased despite decreasing total blood flow in the working muscle after microembolization. The data indicate a shift of blood flow from nutritive to functionally non-nutritive channels.read more
Citations
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Journal ArticleDOI
The concept of a critical oxygen delivery.
Paul T. Schumacker,S. M. Cain +1 more
TL;DR: To the extent this abnormal dependence of VO2 on QO2 reflects tissue hypoxia, clinical interventions which decrease systemic delivery should be evaluated with regard to possible deleterious effects on organ system function.
Journal ArticleDOI
The Effect of the Total Cumulative Epinephrine Dose Administered During Human CPR on Hemodynamic, Oxygen Transport, and Utilization Variables in the Postresuscitation Period
Emanuel P. Rivers,Jacobo Wortsman,Mohamed Y. Rady,Heidi C. Blake,Francis T. McGeorge,Nancy M. Buderer +5 more
TL;DR: The administration of all doses of epinephrine during the resuscitation of out-of-hospital cardiac arrest is associated with impairment of DO2 and VO2 in the postresuscitation period, and inadvertent catecholamine toxicity represents a further complicating factor in the production of postResuscitation disease.
Journal ArticleDOI
Supply Dependency of Oxygen Uptake in ARDS: Myth or Reality?
Stephen M. Cain,Stephen M. Cain +1 more
TL;DR: Evidence is presented that the potential for embolization in ARDS is greatly enhanced by activation of the complement and arachidonic acid cascades as well as by the xanthine oxidase system, which might also account for the increase of supply dependent oxygen demand in AR DS.
Journal ArticleDOI
Peripheral oxygen uptake and delivery in health and disease.
TL;DR: The possible association of O2 supply dependency in the periphery and severe ventilation-perfusion abnormality in the lung during ARDS reminds us that deranged processes that are revealed by relatively routine measurements may not be restricted to a single target organ.
Journal ArticleDOI
Venous Hyperoxia after Cardiac Arrest: Characterization of a Defect in Systemic Oxygen Utilization
Emanuel P. Rivers,Mohamed Y. Rady,Gerard B. Martin,Nancy M. Fenn,Howard A. Smithline,Myrna E. Alexander,Richard M. Nowak +6 more
TL;DR: In this paper, the authors evaluated the clinical significance of mixed venous hyperoxia and its implications for impaired systemic oxygen utilization in post-arrest cardiogenic shock patients and found that inability to attain a VO, of greater than 90 ml/min·m 2 after the first 6 h of aggressive therapy was associated with a 100 percent mortality in 24 h.
References
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Journal ArticleDOI
The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ Method
TL;DR: It is shown that the permeability of a capillary area can be expressed by three parameters: the initial extraction of test substances added in a single injection to the blood flowing to an organ, the blood flow and the surface area of the capillaries.
Journal ArticleDOI
Microvascular dimensions and blood flow in skeletal muscle.
Elof Eriksson,Rhagnar Myrhage +1 more
TL;DR: In cats anesthetized with chloralose the lengths and diameters of the different vascular segments in the tenuissimus muscle were measured in the vital microscope and the flow characteristics, including red cell velocity, were registered.
Journal ArticleDOI
Selective Distribution of Blood Through the Terminal Vascular Bed of Mesenteric Structures and Skeletal Muscle1
TL;DR: In much of the earlier work, the peripheral vascular bed was depicted as an indiscriminately arranged network of capillaries which unite with one another to form venous channels.
Journal ArticleDOI
Effects of alterations of total muscular blood flow on local tissue clearance of radio-iodide in the cat.
TL;DR: It is concluded that most procedures influence the shunt and nutritional blood flow in a proportionate manner, but the active vasodilation resulting from hypothalamic stimulation is restricted to theShunt flow.
Journal Article
Evidence for two vascular pathways in skeletal muscle.
Barlow Te,Haigh Al,Walder Dn +2 more