Journal ArticleDOI
On the origin of RNA splicing and introns.
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This article is published in Cell.The article was published on 1985-09-01. It has received 439 citations till now. The article focuses on the topics: RNA splicing & Intron.read more
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Journal ArticleDOI
Origin of life: The RNA world
TL;DR: L'auteur postule un systeme, auto-replicatif a l'origine uniquement compose de molecules d'ARN.
Journal ArticleDOI
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Donny D. Licatalosi,Aldo Mele,John J. Fak,Jernej Ule,Melis Kayikci,Sung Wook Chi,Tyson A. Clark,Anthony C. Schweitzer,John E. Blume,Xuning Wang,Jennifer C. Darnell,Robert B. Darnell +11 more
TL;DR: A genome-wide means of mapping protein–RNA binding sites in vivo, by high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP), which revealed a large number of Nova–RNA interactions in 3′ untranslated regions, leading to the discovery that Nova regulates alternative polyadenylation in the brain.
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RNA-Catalyzed RNA Polymerization: Accurate and General RNA-Templated Primer Extension
TL;DR: An RNA molecule is described that catalyzes the type of polymerization needed for RNA replication, which uses nucleoside triphosphates and the coding information of an RNA template to extend an RNA primer by the successive addition of up to 14 nucleotides.
Journal ArticleDOI
Splicing of Messenger RNA Precursors
TL;DR: A general mechanism for the splicing of nuclear mRNA precursors in eukaryotic cells has been widely accepted as discussed by the authors, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
Journal ArticleDOI
RNA evolution and the origins of life
TL;DR: It is doubtful that life began with RNA, but consideration of what came before RNA must take into account relevant information from geochemistry, prebiotic chemistry and nucleic acid biochemistry.