Optical frequency domain imaging with a rapidly swept laser in the 815-870 nm range
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TLDR
Optical frequency domain imaging in the 800-nm biological imaging window is demonstrated by using a novel wavelength-swept laser source and may prove useful in comprehensive retinal screening for medical diagnosis and contrast-agent-based imaging for biological investigations.Abstract:
Optical frequency domain imaging (OFDI) in the 800-nm biological imaging window is demonstrated by using a novel wavelength-swept laser source. The laser output is tuned continuously from 815 to 870 nm at a 43.2-kHz repetition rate with 7-mW average power. Axial resolution of 10-µm in biological tissue and peak sensitivity of 96 dB are achieved. In vivo imaging of Xenopus laevis is demonstrated with an acquisition speed of 84 frames per second (512 axial lines per frame). This new imaging technique may prove useful in comprehensive retinal screening for medical diagnosis and contrast-agent-based imaging for biological investigations.read more
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Journal Article
Optical Coherence Tomography of the Human Retina
Michael R. Hee,Joseph A. Izatt,Eric A. Swanson,David Huang,Joel S. Schuman,Charles P. Lin,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: In this article, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.
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Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second
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TL;DR: Improvements in the speed and performance of 3D-OCT volumetric imaging promise to enable earlier diagnosis and improved monitoring of disease progression and response to therapy in ophthalmology, as well as have a wide range of research and clinical applications in other areas.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
Sensitivity advantage of swept source and Fourier domain optical coherence tomography
TL;DR: Results are presented which demonstrate the superior sensitivity of swept source (SS) and Fourier domain (FD) optical coherence tomography (OCT) techniques over the conventional time domain (TD) approach.
Journal ArticleDOI
Optical Coherence Tomography of the Human Retina
Michael R. Hee,Joseph A. Izatt,Eric A. Swanson,David Huang,Joel S. Schuman,Charles P. Lin,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: In this paper, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.
Journal Article
Optical Coherence Tomography of the Human Retina
Michael R. Hee,Joseph A. Izatt,Eric A. Swanson,David Huang,Joel S. Schuman,Charles P. Lin,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: In this article, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.