Optimizing transport of metabolites through large channels: molecular sieves with and without binding.
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Using a diffusion model of molecules moving through a pore, this work rationalizes why biological channels have an affinity for the molecules they have evolved to translocate.About:
This article is published in Biophysical Journal.The article was published on 2005-03-01 and is currently open access. It has received 142 citations till now.read more
Citations
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The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
TL;DR: The bacterial response towards antibiotic stress on altered membrane permeability is outlined and recent advances in molecular approaches that are improving knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channels are discussed.
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Connexin channel permeability to cytoplasmic molecules
TL;DR: The data strongly suggest that highly specific interactions take place between connexin pores and specific biological molecular permeants, and that those interactions determine which cytoplasmic molecules can permeate and how well.
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Solid-state nanopore channels with DNA selectivity
TL;DR: Solid-state nanopore channels that are selective towards single-stranded DNA (ssDNA) are reported, providing a tool to gain fundamental insight into the channel-molecule interactions and the conceptual framework of diffusive molecular transport with particle-channel interactions.
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Diffusion in confined geometries.
TL;DR: In this paper, a single-file diffusion model was proposed to study the entropic effects of stochastic transport of small particles in a static suspension medium with confining walls and constrictions.
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Entropic transport: kinetics, scaling, and control mechanisms.
TL;DR: It is shown that transport in the presence of entropic barriers exhibits peculiar characteristics which makes it distinctly different from that occurring through energy barriers, and this interesting property can be utilized to effectively control transport through quasi-one-dimensional structures in which irregularities or tortuosity of the boundaries causeEntropic effects.
References
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Molecular Basis of Bacterial Outer Membrane Permeability Revisited
TL;DR: This review summarizes the development in the field since the previous review and begins to understand how this bilayer of the outer membrane can retard the entry of lipophilic compounds, owing to increasing knowledge about the chemistry of lipopolysaccharide from diverse organisms and the way in which lipopoly Saccharide structure is modified by environmental conditions.
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Designed to penetrate: Time-resolved interaction of single antibiotic molecules with bacterial pores
TL;DR: It is hypothesized that, in analogy to substrate-specific channels that evolved to bind certain metabolite molecules, antibiotics have “evolved” to be channel-specific.
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Transport of maltodextrins through maltoporin: a single-channel study.
TL;DR: It is found that for all studied sugars, from maltotriose to maltoheptaose, that only one sugar molecule is required to completely block one of the pores in the maltoporin trimer, and the sugar residence time in the pore does not depend on which side the sugar is added.
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Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway.
TL;DR: Hydrophobic interactions with the greasy slide guide the sugar into and through the channel constriction, confer stereospecificity to the channel along with the ability to scavenge substrate at low concentrations.
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ATP Transport Through a Single Mitochondrial Channel, VDAC, Studied by Current Fluctuation Analysis
TL;DR: Results and simple steric considerations indicate pronounced attraction of ATP molecules to VDAC's aqueous pore and permit us to evaluate the effect of a single ATP molecule on channel conductance.