Journal ArticleDOI
Overview of Penicillin Allergy
TLDR
Avoidance of cephalosporins may be recommended in cases of penicillin allergy, but newer generation cep HALsporins have demonstrate less cross-reactivity toPenicillin than earlier generation ones, and desensitization protocols for cep Halosporin are available but not standardized.Abstract:
Allergy to penicillin is the most commonly reported antibiotic allergy. However, most patients who report a positive history of a prior reaction to penicillin are not found to be allergic to penicillin upon skin testing. Often, this history is vague or based on a parent’s recollection of an event that occurred in the distant past. Avoidance of penicillin based on self-reported allergic history alone often leads to the use of an alternate antibiotic with greater cost or side effect profile. Patients with a negative skin test to both major and minor determinants may generally be given penicillin, with a statistical risk of developing an allergic reaction similar to that observed in the general population. A more cautious approach in these cases where the degree of suspicion is low, an allergic etiology is unproven, or there is a negative skin test, is to do a graded challenge. If the skin test is positive, an alternate antibiotic should be used. If, however, an alternate antibiotic is not available, then desensitization may be performed, but there are limitations to desensitization as well, and tolerance is not permanent. Avoidance of cephalosporins may be recommended in cases of penicillin allergy, but newer generation cephalosporins have demonstrate less cross-reactivity to penicillin than earlier generation ones. Desensitization protocols for cephalosporins are available but not standardized. The mechanisms of antibiotic sensitization are not clearly understood.read more
Citations
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Journal ArticleDOI
Cross-reactivity in β-Lactam Allergy
TL;DR: It is concluded that there is ample evidence to allow the safe use of cephalosporins in patients with isolated confirmed penicillin or amoxicillin allergy, and the structural involvement of the R1 and R2 chemical side chains of the cep Halosporin causing IgE-mediated cross-reactivity with penicillins and other cep HALsporins is debated.
Journal ArticleDOI
Improving the Effectiveness of Penicillin Allergy De-labeling.
TL;DR: Infrequent SPT/IDT+ and absent OC reactions in patients with NIM reactions suggest OC alone to be a safe and cost-effective de-labeling strategy that could improve the coverage of penicillin allergy de- labeling in lower risk populations.
Journal ArticleDOI
Penicillin and Cephalosporin allergy
Journal ArticleDOI
Antibiotics for asymptomatic bacteriuria in kidney transplant recipients.
Julien Coussement,Anne Scemla,Daniel Abramowicz,Evi V. Nagler,Angela C Webster,Angela C Webster +5 more
TL;DR: There is insufficient evidence to support routinely treating kidney transplant recipients with antibiotics in case of asymptomatic bacteriuria after transplantation, but data are scarce.
Journal ArticleDOI
Beta-Lactam Hypersensitivity and Cross-Reactivity:
TL;DR: The data reviewed suggest that avoidance of other beta-lactams in patients with type 1 hypersensitivity to penicillins should be reconsidered, and that cross-reactivity with monobactams is essentially negligible.
References
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Journal ArticleDOI
Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations.
Werner Aberer,Andreas J. Bircher,Antonino Romano,Miguel Blanca,Paolo Campi,Javier Fernández,Knut Brockow,Werner J. Pichler,Pascal Demoly +8 more
TL;DR: A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself.
Journal ArticleDOI
Delayed Drug Hypersensitivity Reactions
TL;DR: This review presents newer concepts of the role of T cells in drug hypersensitivity, which evolved from the study of drug-specific T Cells in various drug-induced hypersensitivity diseases.
Journal ArticleDOI
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis
Wen-Hung Chung,Wen-Hung Chung,Shuen-Iu Hung,Shuen-Iu Hung,Jui-Yung Yang,Shih-Chi Su,Shien-Ping Huang,Chun-Yu Wei,See-Wen Chin,Chien-Chun Chiou,Sung-Chao Chu,Hsin-Chun Ho,Chih-Hsun Yang,Chi-Fang Lu,Jer-Yuarn Wu,You-Di Liao,Yuan-Tsong Chen,Yuan-Tsong Chen +17 more
TL;DR: It is demonstrated that secretory granulysin is a key molecule responsible for the disseminated keratinocyte death in SJS-TEN and this work highlights a mechanism for CTL- or NK cell—mediated cytotoxicity that does not require direct cellular contact.
Journal ArticleDOI
Diagnosis of immediate allergic reactions to beta‐lactam antibiotics
María José Torres,Miguel Blanca,Javier Fernández,Antonino Romano,A.L. de Weck,Werner Aberer,Knut Brockow,Werner J. Pichler,Pascal Demoly +8 more
TL;DR: Allergic reactions to betalactams are the most common cause of adverse drug reactions mediated by specific immunological mechanisms and the number of reactions has not decreased, although the production process of betAlactams has improved over the years.
Journal Article
Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock.
TL;DR: An appraisal is made of toxic, microbiogenic, and allergic side effects occurring in man as a result of large amounts of penicillin increasingly used in medical and veterinary practice, including a study of 151 anaphylactic fatalities reported to have followedPenicillin administration.
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