Journal ArticleDOI
Oxidation of unsaturated fatty acids by ozone and nitrogen dioxide. A common mechanism of action
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Oxidation of essential tissue polyunsaturated fatty acids by O3 and NO2 is a likely common mechanism of toxicity.Abstract:
Trace quantities of ozone and nitrogen dioxide, 1.5 ppm, catalyzed the rapid oxidation of unsaturated fatty acids. Nitrogen dioxide-catalyzed oxidations were dependent upon the NO2 concentration in the atmosphere. Both thin films and aqueous emulsions of fatty acids are oxidized by NO2 through a mechanism akin to the spontaneous autoxidation in air. Phenolic antioxidants, including vitamin E, retarded the oxidation. Ozone catalyzed a more rapid and complete oxidation than NO2 by a direct attack upon the double bonds of the fatty acid. Phenolic antioxidants are protective only in aqueous emulsions where the oxidation proceeds by peroxidation as well. Oxidation of essential tissue polyunsaturated fatty acids by O3 and NO2 is a likely common mechanism of toxicity.read more
Citations
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Journal ArticleDOI
Autoxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA-reactive materials from prostaglandin-like endoperoxides.
TL;DR: The nature and mechanism of formation of the thiobarbituric acid (TBA)-reactive material produced in the autoxidation of polyunsaturated fatty acids (PUFA) or their esters has been studied.
Book ChapterDOI
CHAPTER 2 – Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes
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Tansley Review No. 24 Why are atmospheric oxides of nitrogen usually phytotoxic and not alternative fertilizers
TL;DR: This review considers their uptake into foliage, as well as their subsequent metabolism and physiology, and attempts to explain why these gases are often phytotoxic.
Journal ArticleDOI
Mechanisms of radical formation from reactions of ozone with target molecules in the lung.
TL;DR: From the effects of temperature, metal chelators, and water, it is concluded that ozone reacts by the Criegee ozonation pathway to give the classical 1,2,3-trioxolane, which then undergoes O--O bond homolysis to form a diradical.
References
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Journal ArticleDOI
A distillation method for the quantitative determination of malonaldehyde in rancid foods
TL;DR: An improved distillation method is described for the quantitative determination of malonaldehyde in foods containing oxidized fats and a high correlation of TBA numbers with rancid odor in cooked meats was established.
Journal ArticleDOI
The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters.
TL;DR: The mechanism of oxidation of methylene-interrupted trienes, tetraenes, pentaenes, and hexaenes postulates an additional step in chain propagation involving intramolecular rearrangement of the hydroperoxy free radical to a free radical bearing a closed five-membered ring peroxide.
Journal ArticleDOI
Colorimetric Microdetermination of Nitrogen Dioxide in Atmosphere
TL;DR: In this article, a mixture of sulfanilic acid, N-(1-naphthyl)-ethylenediamine dihydrochloride, and acetic acid was used to detect nitrogen dioxide.
Journal ArticleDOI
Lipoperoxidation of Lung Lipids in Rats Exposed to Nitrogen Dioxide
TL;DR: Absorption spectra characteristic of diene conjugation and typical for peroxidized polyenoic fatty acids can be induced in rat lung lipids after the rats have been exposed to a scant amount of nitrogen dioxide.