Oxidizing intermediates in the reaction of ferrous EDTA with hydrogen peroxide. Reactions with organic molecules and ferrocytochrome c.
J. D. Rush,Willem H. Koppenol +1 more
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The reaction between hydrogen peroxide and ferrous EDTA generates an oxidizing intermediate (I1) which is not the hydroxyl radical but shows a pattern of reactivity more associated with a metal ion oxidant like a ferryl (FeO2+)-EDTA complex.About:
This article is published in Journal of Biological Chemistry.The article was published on 1986-05-25 and is currently open access. It has received 198 citations till now. The article focuses on the topics: Hydroxyl radical & Hydrogen peroxide.read more
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Advanced Oxidation Processes for Organic Contaminant Destruction Based on the Fenton Reaction and Related Chemistry
TL;DR: In this paper, the complex mechanisms of Fenton and Fenton-like reactions and the important factors influencing these reactions, from both a fundamental and practical perspective, in applications to water and soil treatment, are discussed.
Journal ArticleDOI
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.
TL;DR: An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide.
Journal ArticleDOI
Toxicity of iron and hydrogen peroxide: the Fenton reaction
TL;DR: The mechanism and how it is affected by different chelators, and the interpretation of results obtained in biological systems, are discussed.
Journal ArticleDOI
Reactions of oxyl radicals with DNA.
Anthony P. Breen,John A. Murphy +1 more
TL;DR: This review focuses on the damage caused to DNA by reactive oxygen-centred radicals, which arise either from the radiolysis of water by ionizing radiation, or from a purely chemical source.
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Journal ArticleDOI
Role of metals in oxygen radical reactions
TL;DR: Factors such as pH and chelation govern the reactivity of the transition metals with dioxygen and "oxy-radicals" and therefore influence the apparent mechanisms by which oxidative damage to phospholipids, DNA, and other biomolecules is initiated.
Journal ArticleDOI
Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.
TL;DR: The hypothesis that iron-catalyzed formation of hydroxyl radical from superoxide anion radical (O-.2) and H2O2 requires the availability of at least one iron coordination site that is open or occupied by a readily dissociable ligand such as water is investigated.
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Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex.
TL;DR: Reaction 1 was the simplest explanation accommodating all the observed facts, and the reaction had been proposed many years earlier by Haber and Weiss during their studies of the catalytic decomposition of hydrogen peroxide by iron salts.
Journal ArticleDOI
The oxidizing nature of the hydroxyl radical. A comparison with the ferryl ion (FeO2
TL;DR: In this paper, the authors trouve dans la litterature les valeurs: 2,0 and 1,4 V for le potentiel de reduction standard du couple radical hydroxyl/hydroxyde.