Journal ArticleDOI
Oxygen tension regulates the expression of angiogenesis factor by macrophages
David R. Knighton,Thomas K. Hunt,Heinz Scheuenstuhl,Betty J. Halliday,Zena Werb,Michael J. Banda +5 more
TLDR
The control of angiogenesis in wound healing may be the result of macrophages responding to tissue oxygen tension without the necessity of interacting with other cell types or biochemical signals.Abstract:
When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those of well-oxygenated tissue, macrophages did not secrete active angiogenesis factor. Macrophages that secreted the factor at hypoxic conditions stopped secreting it when returned to room air. Thus the control of angiogenesis in wound healing may be the result of macrophages responding to tissue oxygen tension without the necessity of interacting with other cell types or biochemical signals.read more
Citations
More filters
Journal ArticleDOI
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.
Journal ArticleDOI
Global initiative for chronic obstructive lung disease.
Lynn B. Gerald,William C. Bailey +1 more
TL;DR: Representatives from many countries serve as a network for the dissemination and implementation of programs for diagnosis, management, and prevention of COPD.
Journal ArticleDOI
Regulation of angiogenesis by hypoxia: role of the HIF system.
TL;DR: The role of HIF in developmental, adaptive and neoplastic angiogenesis, and the implications of oncogenic activation of extensive, physiologically interconnected hypoxia pathways for the tumor phenotype are discussed.
Journal ArticleDOI
Wound healing: an overview of acute, fibrotic and delayed healing.
TL;DR: This review describes the major biological processes associated with both normal and pathologic healing of acute wounds, characterized by four distinct, but overlapping phases: hemostasis, inflammation, proliferation and remodeling.
References
More filters
Journal ArticleDOI
Isolation of a tumor factor responsible for angiogenesis
TL;DR: It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.
Journal ArticleDOI
Polymers for the sustained release of proteins and other macromolecules
Robert Langer,Judah Folkman +1 more
TL;DR: This work presents a simple method for incorporating various proteins and other macromolecules into non-inflammatory polymers and demonstrates sustained release of biochemically active macromolescules for periods exceeding 100 d.
Journal ArticleDOI
Activated macrophages induce vascular proliferation
TL;DR: It is reported here that macrophages activated in vivo and in vitro, and media conditioned by these cells, induce vascular proliferation in the guinea pig cornea.
Related Papers (5)
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
Activated macrophages induce vascular proliferation
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more