Journal ArticleDOI
Parasite and Host Erythrocyte Kinomics of Plasmodium Infection
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TLDR
In this paper, an overview of the updated kinome of Plasmodium falciparum, the species that is the largest contributor to malaria mortality, and current knowledge pertaining to the function of parasite-encoded protein kinases during the parasite's life cycle is presented.About:
This article is published in Trends in Parasitology.The article was published on 2021-02-13. It has received 13 citations till now. The article focuses on the topics: Kinome & Plasmodium falciparum.read more
Citations
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Host-directed therapy, an untapped opportunity for antimalarial intervention.
Ling Wei,Jack D. Adderley,Didier Leroy,David H. Drewry,Danny W. Wilson,Danny W. Wilson,Alexis Kaushansky,Alexis Kaushansky,Christian Doerig +8 more
TL;DR: Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases caused by viruses and intracellular bacteria, but its implementation in the context of parasitic diseases has received less attention as mentioned in this paper.
Journal ArticleDOI
How Many Is Enough? - Challenges of Multinucleated Cell Division in Malaria Parasites.
TL;DR: In this article, the authors provide a comparative quantification of merozoite numbers in several P. knowlesi and P. falciparum strains, and discuss the general processes that may regulate progeny number in the context of host-parasite interactions.
Posted ContentDOI
Gene-by-gene screen of the unknown proteins encoded on P. falciparum chromosome 3
Jessica Kimmel,Marius Schmitt,Alexej Sinner,Pascal W.T.C. Jansen,Sheila Mainye,Gala Ramón-Zamorano,Christa Geeke Toenhake,J. Stephan Wichers,Jakob Cronshagen,Ricarda Sabitzki,Paolo Mesén-Ramírez,Hannah M. Behrens,Richárd Bártfai,Tobias Spielmann +13 more
TL;DR: The feasibility of gene-by-gene screens to elucidate the biology of malaria parasites and reveal critical parasite-specific processes of interest as drug targets is demonstrated.
Journal ArticleDOI
Gene-by-gene screen of the unknown proteins encoded on Plasmodium falciparum chromosome 3.
Jessica Kimmel,Marius Schmitt,Alexej Sinner,Pascal Wilhelmus Theodorus Christianus Jansen,Sheila Mainye,Gala Ramón-Zamorano,Christa Geeke Toenhake,J. S. Wichers-Misterek,Jakob Cronshagen,Ricarda Sabitzki,Paolo Mesén-Ramírez,Hannah M. Behrens,Richárd Bártfai,Tobias Spielmann +13 more
TL;DR: Rancati et al. as mentioned in this paper analyzed the cellular location, essentiality, function, and, in selected cases, interactome of all unknown non-secretory proteins encoded on an entire P. falciparum chromosome.
Journal ArticleDOI
Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
TL;DR: In this paper , a structural-validated multiple sequence alignment (MSA) of the human kinome is used as a scaffold to assist the alignment of all protein kinase sequences from P. falciparum and P. vivax, and their assignment to specific kinase groups/families.
References
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Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
Fabian Sievers,Andreas Wilm,David Dineen,Toby J. Gibson,Kevin Karplus,Weizhong Li,Rodrigo Lopez,Hamish McWilliam,Michael Remmert,Johannes Söding,Julie D. Thompson,Desmond G. Higgins +11 more
TL;DR: A new program called Clustal Omega is described, which can align virtually any number of protein sequences quickly and that delivers accurate alignments, and which outperforms other packages in terms of execution time and quality.
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Jalview Version 2--a multiple sequence alignment editor and analysis workbench.
TL;DR: Jalview 2 is a system for interactive WYSIWYG editing, analysis and annotation of multiple sequence alignments that employs web services for sequence alignment, secondary structure prediction and the retrieval of alignments, sequences, annotation and structures from public databases and any DAS 1.53 compliant sequence or annotation server.
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TL;DR: Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
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Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees
Ivica Letunic,Peer Bork +1 more
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