Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload
Ne N. Wu,Yaguang Bi,Amir Ajoolabady,Fei You,James R. Sowers,Qiurong Wang,Aslı Ceylan,Yingmei Zhang,Jun Ren +8 more
TLDR
Parkin deficiency unmasked HFD-induced decline in voltage-dependent anion channel (VDAC) type 1 degradation through the ubiquitin-proteasome system but not other VDAC isoforms or mitochondrial Ca2+ uniporter complex as discussed by the authors .About:
This article is published in JACC: Basic to Translational Science.The article was published on 2022-08-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Medicine & Parkin.read more
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TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury.
TL;DR: In this article , the role of transmembrane BAX inhibitor motif containing 6 (TMBIM6) in septic cardiomyopathy (SCM) was evaluated using mice.
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Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis.
Jie Min,Lin Wu,Yan-dong Liu,Guoliang Song,Qinqin Deng,Wei Jin,Wei Yu,Abudureyimu Miyesaier,Zhaohui Pei,J. Ren +9 more
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The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease
TL;DR: In this paper , the major factors of mitochondrial metabolism and their potential roles in the prevention and treatment of cardiovascular disease are discussed and the current application of mitochondria-targeted therapeutic agents in the treatment of CVD and advances in mitochondriatargeted gene therapy technologies are also overviewed.
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Interplay between obesity and aging on myocardial geometry and function: Role of leptin-STAT3-stress signaling
TL;DR: In this article , the interaction between obesity and aging on cardiac remodeling and contractile function was examined in young and old ob/ob mice, and the effect of obesity on cardiac function was investigated.
References
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler,Kira M. Holmström,Diana Skujat,Fabienne C. Fiesel,Oliver Rothfuss,Philipp J. Kahle,Wolfdieter Springer +6 more
TL;DR: Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
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Obesity Phenotypes, Diabetes, and Cardiovascular Diseases
TL;DR: It is proposed that obesity can no longer be evaluated solely by the body mass index (expressed in kg/m2) because it represents a heterogeneous entity and should be referred to obesities rather than obesity.
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Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
George M. Burslem,Craig M. Crews +1 more
TL;DR: The burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-proteasome system, are described and their application to drug discovery is described.
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Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
TL;DR: The most important conclusion relevant to heart disease is that regulated forms of cardiomyocyte death play important roles in both myocardial infarction with reperfusion (ischemia/reperfusion) and heart failure.
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Mitochondrial Regulation of Cell Death
TL;DR: The mechanisms underlying mitochondrial permeabilization are discussed and how this key event leads to cell death through caspase-dependent and -independent means, and how the release of mitochondrial proteins may be regulated following MOMP is explored.