Open AccessJournal Article
Pelvic Organ Prolapse
TLDR
The cause of prolapse is primarily associated with pregnancy and vaginal delivery, which lead to direct pelvic floor muscle and connective tissue injury, and conditions associated with sustained episodes of increased intra-abdominal pressure, including obesity, chronic cough, constipation, and repeated heavy lifting.Abstract:
Pelvic organ prolapse is the descent of one or more of the anterior vaginal wall, posterior vaginal wall, the uterus (cervix), or the apex of the vagina (vaginal vault or cuff scar after hysterectomy). Prevalence increases with age. The cause of prolapse is multifactorial but is primarily associated with pregnancy and vaginal delivery, which lead to direct pelvic floor muscle and connective tissue injury. Hysterectomy, pelvic surgery, and conditions associated with sustained episodes of increased intra-abdominal pressure, including obesity, chronic cough, constipation, and repeated heavy lifting, also contribute to prolapse. Most patients with pelvic organ prolapse are asymptomatic. Symptoms become more bothersome as the bulge protrudes past the vaginal opening. Initial evaluation includes a history and systematic pelvic examination including assessment for urinary incontinence, bladder outlet obstruction, and fecal incontinence. Treatment options include observation, vaginal pessaries, and surgery. Most women can be successfully fit with a vaginal pessary. Available surgical options are reconstructive pelvic surgery with or without mesh augmentation and obliterative surgery.read more
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Iconographies supplémentaires de l'article : Pelvic Organ Support Study (POSST): The distribution, clinical definition, and epidemiologic condition of pelvic organ support defects
Steven Swift,Patrick J. Woodman,Amy L. O'Boyle,Margie Kahn,Michael Valley,Deirdre R. Bland,Wei Wang,Joe Schaffer +7 more
TL;DR: In this paper, the authors describe the distribution of pelvic organ support in a gynecologic clinic population to define the clinical disease state of pelvic organs prolapse and to analyze its epidemiologic condition.
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Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor.
Shayanti Mukherjee,Shayanti Mukherjee,Saeedeh Darzi,Saeedeh Darzi,Kallyanashis Paul,Kallyanashis Paul,Fiona L. Cousins,Fiona L. Cousins,Jerome A. Werkmeister,Jerome A. Werkmeister,Caroline E. Gargett,Caroline E. Gargett +11 more
TL;DR: eMSC modulate the foreign body response to degradable P nanomeshes in vivo by altering the expression profile of mouse genes, suggesting significant potential as alternative surgical constructs for the treatment of POP.
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Pelvic organ prolapse and sexual function.
TL;DR: Although long disparaged, vaginal surgery can be offered to sexually active patients provided the principles of good practice are followed and the incidence of de novo dyspareunia and the global Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire score is not different between vaginal repair with or without mesh.
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Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)
TL;DR: It is probable that other mechanisms that can also cause POP exist during cell senescence, which necessitates further research and provides new directions in the development of novel medical treatment, stem cell therapy and non-surgical interventions for POP.
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Diagnostic value of pelvic floor ultrasonography for diagnosis of pelvic organ prolapse: a systematic review
TL;DR: P pelvic floor ultrasound is valuable in diagnosing POP, yet suffers from a weakness in precision compared with physical examination, and current methods have advantages and limitations.
References
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Journal ArticleDOI
Prevalence of symptomatic pelvic floor disorders in US women
Ingrid Nygaard,Matthew D. Barber,Kathryn L. Burgio,Kathryn L. Burgio,Kimberly Kenton,Susan Meikle,Joseph I. Schaffer,Cathie Spino,William E. Whitehead,Jennifer M. Wu,Debra J. Brody +10 more
TL;DR: A cross-sectional analysis of 1961 nonpregnant women who participated in the 2005-2006 National Health and Nutrition Examination Survey, a nationally representative survey of the US noninstitutionalized population, found no differences in prevalence by racial/ethnic group.
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Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women
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An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction
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TL;DR: The prevalence of pelvic floor disorders will increase substantially given the changing demographics in the United States and this increase has important implications for public health and the field of gynecology.
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Prevalence and Trends of Symptomatic Pelvic Floor Disorders in U.S. Women
Jennifer M. Wu,Camille P. Vaughan,Patricia S. Goode,David T. Redden,David T. Redden,David T. Redden,Kathryn L. Burgio,Kathryn L. Burgio,Kathryn L. Burgio,Holly E. Richter,Holly E. Richter,Holly E. Richter,Alayne D. Markland,Alayne D. Markland,Alayne D. Markland +14 more
TL;DR: Although rates of pelvic floor disorders did not change from 2005 to 2010, these conditions remain common, with one fourth of adult U.S. women reporting at least one disorder.