Journal ArticleDOI
Pharmaceutical and Medical Aspects of Bioadhesive Systems for Drug Administration
TLDR
Methods of studying bioadhesion are described as well as the existing bioadhesive dosage forms, which include polycarbophil a Carbopol 934, and low chemical bonds.Abstract:
Bioadhesion could lead to the solution of bioavailability problems resulting from a too short stay of the pharmaceutical dosage form at the absorption or activity level of the active ingredient. Bioadhesion stages are: intimate contact resulting from a good wetting of the bioadhesion surface and the swelling of the bioadhesive polymer, then penetration of the bioadhesive into the crevice of the tissue surface or interpenetration of bioadhesive chains with those of the mucus, and finally low chemical bonds. date, the most important bioadhesive polymers are polycarbophil a Carbopol 934. Methods of studying bioadhesion are described as well as the existing bioadhesive dosage forms.read more
Citations
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Journal ArticleDOI
Buccal bioadhesive drug delivery--a promising option for orally less efficient drugs.
TL;DR: The developments in the buccal adhesive drug delivery systems are reviewed to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design.
Journal ArticleDOI
Ophthalmic drug delivery systems—Recent advances
TL;DR: In this paper, the authors focus on three representative areas of ophthalmic drug delivery systems: polymeric gels, colloidal systems, cyclodextrins and collagen shields.
Journal ArticleDOI
Bioadhesive‐Based Dosage Forms: The Next Generation
TL;DR: The present mini-review will remind us of the success achieved with these first-generation polymers and focus on proposals for the next-generationpolymers and attendant benefits likely to occur with these improved polymeric systems.
Journal ArticleDOI
Hydrogels as mucoadhesive and bioadhesive materials: a review
TL;DR: This review addresses several issues which clarify the central goals of bioadhesive drug delivery research and presents an overview of several proposed mechanisms of adhesion.
Journal ArticleDOI
Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives.
TL;DR: New classes of functionalized mucoadhesive polymers, the characterization and safety aspects of nasal drug products as well as the opportunities presented by nasal drug delivery are extensively discussed.
References
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Journal ArticleDOI
Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
Nicholas A. Peppas,Pierre Buri +1 more
TL;DR: In this article, the nature of the adhesive interface, the surface roughness, the chemical structure of the bioadhesive-candidate material, the swelling (hydration) at the adhesive interfaces, and the dynamic development of the bond strength are analyzed in terms of molecular and surface theories.
Journal ArticleDOI
An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery
TL;DR: An in‐vitro test system was developed to investigate the adhesiveness of various materials to mucus, and it was found that these materials become adhesive on hydration.
Journal ArticleDOI
Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion
Kinam Park,Joseph R. Robinson +1 more
TL;DR: To examine a large number of polymers as to their bioadhesive potential and to derive meaningful information on the structural requirements for bioadhesion a new, simple experimental technique that can quantitatively measure bioad adhesive properties of various polymers has been developed.
Journal ArticleDOI
The healing process at polymer–polymer interfaces
Stephen Prager,Matthew Tirrell +1 more
TL;DR: In this article, an analysis of the welding process based on the reptation picture of polymer dynamics due to de Gennes was presented. But the analysis was restricted to the case when two pieces of the same amorphous polymer are brought into contact at a temperature above the glass transition, the junction surface gradually heals until, at very long contact times, it is indistinguishable from bulk polymer.
Journal ArticleDOI
Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion☆
Haesun Park,Joseph R. Robinson +1 more
TL;DR: In this article, structural features of the adhesive polymer were explored using a copolymer of acrylic and methacrylic acid with variation in charge density and hydrophobicity of the molecules.
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Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
Nicholas A. Peppas,Pierre Buri +1 more