Journal ArticleDOI
Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion☆
Haesun Park,Joseph R. Robinson +1 more
TLDR
In this article, structural features of the adhesive polymer were explored using a copolymer of acrylic and methacrylic acid with variation in charge density and hydrophobicity of the molecules.About:
This article is published in Journal of Controlled Release.The article was published on 1985-11-01. It has received 256 citations till now. The article focuses on the topics: Polymer.read more
Citations
More filters
Journal ArticleDOI
Ophthalmic drug delivery systems—Recent advances
TL;DR: In this paper, the authors focus on three representative areas of ophthalmic drug delivery systems: polymeric gels, colloidal systems, cyclodextrins and collagen shields.
Journal ArticleDOI
The use of mucoadhesive polymers in buccal drug delivery.
TL;DR: A review of the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, followed by the recent mucoadhesive formulations for buccal drug delivery.
Journal ArticleDOI
Bioadhesive‐Based Dosage Forms: The Next Generation
TL;DR: The present mini-review will remind us of the success achieved with these first-generation polymers and focus on proposals for the next-generationpolymers and attendant benefits likely to occur with these improved polymeric systems.
Journal ArticleDOI
Hydrogels as mucoadhesive and bioadhesive materials: a review
TL;DR: This review addresses several issues which clarify the central goals of bioadhesive drug delivery research and presents an overview of several proposed mechanisms of adhesion.
Journal ArticleDOI
Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives.
TL;DR: New classes of functionalized mucoadhesive polymers, the characterization and safety aspects of nasal drug products as well as the opportunities presented by nasal drug delivery are extensively discussed.
References
More filters
Journal ArticleDOI
Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion
Kinam Park,Joseph R. Robinson +1 more
TL;DR: To examine a large number of polymers as to their bioadhesive potential and to derive meaningful information on the structural requirements for bioadhesion a new, simple experimental technique that can quantitatively measure bioad adhesive properties of various polymers has been developed.
Journal ArticleDOI
Intestinal mucins in health and disease.
TL;DR: Recent advances in understanding of mucin structure, secretion and functional properties are reviewed and implications for diseases such as cystic fibrosis, peptic ulcer, malignancy and inflammatory bowel disease are briefly discussed.
Journal ArticleDOI
Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach
TL;DR: Endogenous surfactants are discussed for their capability to provide a cohesive and strongly adsorbed protective monolayer--a physical model for the gastric mucosal barrier compatible with the major properties of the gastrics lining and many features of ulcerogenesis, including the protection afforded by prostaglandins.
Journal ArticleDOI
Gastric gel mucus thickness: effect of distention, 16,16-dimethyl prostaglandin e2, and carbenoxolone.
Martin Bickel,Gordon L. Kauffman +1 more
TL;DR: In this article, the authors measured the thickness of the layer of insoluble geJ mucus lying on the gastric mucosa by using a slit lamp and an image-splitting system known as a pachymeter.
Related Papers (5)
Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
Nicholas A. Peppas,Pierre Buri +1 more