Journal ArticleDOI
Pharmacological characteristics of cyclohexylamine, one of metabolites of cyclamate
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This article is published in Life Sciences.The article was published on 1969-08-01. It has received 11 citations till now. The article focuses on the topics: Cyclohexylamine.read more
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Journal ArticleDOI
Toxicological aspects of cyclamate and cyclohexylamine.
TL;DR: This review of the published and unpublished literature on cyclamate attempts to evaluate the carcinogenicity question and other important aspects of the toxicity of cyclamate and cyclohexylamine, including their effects on various organ systems, their genotoxic potential, and their effect on reproduction.
Journal ArticleDOI
Short-term toxicity of cyclohexylamine hydrochloride in the rat
TL;DR: The testis weight and relativetestis weight were reduced and histopathological examination showed reduced spermatogenesis, however, the rats remained fertile and there was no evidence of abnormalities in their off-spring.
Journal ArticleDOI
Testicular responses of rats and dogs to cyclohexylamine overdosage
R.W. James,R. Heywood,D. Crook +2 more
TL;DR: Quantitative assessment of testicular spermatogenesis showed that CHA administration reduced the counts of pachytene sperMatocytes, and of early and late sper matids, in both species, and these effects were apparently reversible in dogs but not in rats.
Reference EntryDOI
Aliphatic and Alicyclic Amines
TL;DR: Aliphatic and alicyclic amines are nonaromatic amines that have a straight chain, a branched chain, or a cyclic alkyl moiety attached to the nitrogen atom.
Journal ArticleDOI
Cyclohexylamine production and physiological measurements in subjects ingesting sodium cyclamate
M.H. Litchfield,A.A.B. Swan +1 more
TL;DR: It was concluded that no pharmacologically active concentrations of cyclohexylamine were reached in the tissues of these subjects capable of metabolizing cyclamate after daily ingestion of large amounts of cyclamate for a week or more.
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Journal ArticleDOI
A new series of potent analgesics
TL;DR: A potent analgesic and a potent atropine-like substanc615, which sort of activity predominates seems to depend, in the first place, upon the nature of substituent R of structure 1.
Journal ArticleDOI
Studies on Synthetic Sweetening Agents. VIII. Cyclohexylamine, a Metabolite of Sodium Cyclamate
Shoji Kojima,Hisashi Ichibagase +1 more
TL;DR: The urinary metabolic product of CHS-Na in human, rabbit, and dog was studied and cyclohexylamine was found in the urine from human and dog which were received CHS -Na orally.
Journal ArticleDOI
Urinary excretion of cyclohexylamine following oral administration of sodium cyclamate to man
Journal ArticleDOI
Conversion of cyclamate to cyclohexylamine in rats.
TL;DR: The urine of five male laboratory workers for 5 days after each had been given a single dose of 3 g sodium cyclamate was analysed and one of the five subjects was found to excrete 0.8 per cent of the dose of cyclamate which was administered as cyclohexylamine; most of thedose was excreted as free cyclamate.