S
Sidney Green
Researcher at Food and Drug Administration
Publications - 55
Citations - 2534
Sidney Green is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Bone marrow & Hycanthone. The author has an hindex of 22, co-authored 55 publications receiving 2407 citations. Previous affiliations of Sidney Green include Dow Chemical Company & Howard University.
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Journal ArticleDOI
Toxicity testing in the 21st century: a vision and a strategy
Daniel Krewski,Daniel Acosta,Melvin E. Andersen,Henry A. Anderson,John C. Bailar,Kim Boekelheide,Robert L. Brent,Gail Charnley,Vivian G. Cheung,Sidney Green,Karl T. Kelsey,Nancy I. Kerkvliet,Abby A. Li,Lawrence E. McCray,Otto A. Meyer,Reid D. Patterson,William D. Pennie,Robert A. Scala,Gina Solomon,Martin L. Stephens,James D. Yager,Lauren Zeise +21 more
TL;DR: Implementation of a new toxicity testing paradigm firmly based on human biology by transitioning from current expensive and lengthy in vivo testing with qualitative endpoints to in vitro toxicity pathway assays on human cells or cell lines using robotic high-throughput screening with mechanistic quantitative parameters.
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Current status of bioassays in genetic toxicology — The dominant lethal assay: A report of the U.S. environmental protection agency gene-tox program☆
Sidney Green,Angela E. Auletta,Jill D. Fabricant,Robert W. Kapp,Madhu Manandhar,C.W. Sheu,Janet A. Springer,Brad Whitfield +7 more
TL;DR: The role of the assay should be that of confirming positive results from lower tier chromosomal aberration-detecting systems (confirming in the sense of indicating the ability of the chemical to penetrate gonadal tissue and to produce cytogenetic damage).
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Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.
TL;DR: There was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks in rats injected with cyclohexylamine.
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Biochemical and cytogenetic effects in rats caused by short-term ingestion of Aroclor 1254 or Firemaster BP6.
L. H. Garthoff,Leonard Friedman,T.M. Farber,K. K. Locke,Thomas J. Sobotka,Sidney Green,N. E. Hurley,E. L. Peters,G. E. Story,F. M. Moreland,C. H. Graham,J. E. Keys,M. J. Taylor,J. V. Scalera,J. E. Rothlein,E. M. Marks,F. E. Cerra,S. B. Rodi,E. M. Sporn +18 more
TL;DR: Some apparent differences in biochemical responses determined at sacrifice may have been partly due to the fact that, for the 3 wk study, rats were exposed to FM 48 hr longer than to ARO, and thus the comparison of ARO and FM toxiclties should be considered tentative.
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Cytogenetic effects of DDT and derivatives of DDT in a cultured mammalian cell line.
TL;DR: The p,p′-isomers of DDT, DDD and DDE produced a 2-fold increase in chromosome abnormalities as compared with their corresponding o,p–isomers and control cells exhibited no exchange figures; none was observed with p,pt-DDA.