Open AccessJournal Article
Pharmacological treatment following experimental cerebral infarction: implications for understanding psychological symptoms of human stroke.
R G Robinson,Floyd E. Bloom +1 more
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TLDR
The results suggest that ischemic damage to the cerebral cortex which injures some axonal branches of elaborately arborizing catecholamine-containing neurons may alter the biochemical and functional state of the entire system in its intact collateral axons.About:
This article is published in Biological Psychiatry.The article was published on 1977-10-01 and is currently open access. It has received 61 citations till now. The article focuses on the topics: Stroke & Cerebral infarction.read more
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Mood change following left hemispheric brain injury.
Robert G. Robinson,Brian Szetela +1 more
TL;DR: Depression following left hemispheric brain injury may not be a nonspecific neurological or psychological response, but rather may be a symptom of injury to specific pathways, such as the catecholamine‐containing ones, as they pass through the frontal cortex.
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Differential behavioral and biochemical effects of right and left hemispheric cerebral infarction in the rat.
TL;DR: Following ligation of the right middle cerebral artery, rats were hyperactive for 2 to 3 weeks and did not show any significant change in catecholamines in any of the brain areas studied, suggesting lateralization of behavioral and biochemical response to cerebral infarction may be the consequence of anatomical or physiological asymmetries in the brain.
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The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines.
Gianfranco Spalletta,Paola Bossù,Antonio Ciaramella,Pietro Bria,Carlo Caltagirone,Robert G. Robinson +5 more
TL;DR: The evidence supporting the hypothesis that proinflammatory cytokines are involved in the occurrence of stroke as well as mood disorders linked to the brain damage is reviewed.
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Post-stroke depression: mechanisms, translation and therapy.
Isabelle Loubinoux,Golo Kronenberg,Matthias Endres,Pascale Schumann-Bard,Thomas Freret,Robert K. Filipkowski,Leszek Kaczmarek,Aurel Popa-Wagner +7 more
TL;DR: Animal models of PSD are presented and potential underlying mechanisms including genomic signatures, neurotransmitter and neurotrophin signalling, hippocampal neurogenesis, cellular plasticity in the ischaemic lesion, secondary degenerative changes, activation of the hypothalamo‐pituitary‐adrenal (HPA) axis and neuroinflammation are summarized.
Journal ArticleDOI
The differential effect of right versus left hemispheric cerebral infarction on catecholamines and behavior in the rat.
TL;DR: There are no demonstrable effects of left hemispheric infarction on either spontaneous activity or brain catecholamine concentrations following right middle cerebral artery ligation in rats, and this asymmetry of behavioral and biochemical response to cerebral infarctions cannot be attributed to differences in the lesion size produced in either hemisphere.