Photoredox-Catalyzed Synthesis of Remote Fluoroalkylated Azaarene Derivatives and the α-Deuterated Analogues via 1,n-Hydrogen-Atom-Transfer-Involving Radical Reactions.
TLDR
In this paper, a modular strategy to access the remote fluoroalkylated azaarene derivatives and the α-deuterated analogues, which are the isosteres of many pharmaceutically important compounds, is reported.About:
This article is published in Organic Letters.The article was published on 2021-11-01 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Photoredox catalysis.read more
Citations
More filters
Journal ArticleDOI
Difluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer.
Zhi-Qi Zhang,Yueqian Sang,Cheng-Qiang Wang,Peng Dai,Xiao-Song Xue,Jared L. Piper,Zhihua Peng,Jun An Ma,Fa-Guang Zhang,Jie Wu +9 more
TL;DR: In this paper , a photocatalytic radical hydrodifluoromethylation of unactivated alkenes with an inexpensive industrial chemical, chlorodifluorsomethane (ClCF2H, Freon-22), was proposed.
Journal ArticleDOI
Radical Addition to C=C Bond Meets (1,n)-HAT: Recent Advances on Remote C(sp3)-H or C(sp2)-H Functionalization of Alkenes
Jiubai Xi,Wei-Wei Liao +1 more
TL;DR: In recent years, remarkable advances on remote C(sp3)-H bond or aldehydic C( sp2)-H functionalizations enabled by intermolecular radical addition to C=C bond/(1,n)-HAT tandem sequences have been witnessed.
Journal ArticleDOI
Synergistic Visible Light and Pd-Catalyzed C-H Alkylation of 1-Naphthylamines with α-Diazoesters.
TL;DR: In this article , the combination of visible light irradiation and Pd-catalysis has been practically employed for the C-H alkylation reactions of naphthylamines and α-diazo esters, leading to the synthesis of α-naphthyl functionalized acetates via C-C bond construction under mild reaction conditions and under solvent-free conditions.
Journal ArticleDOI
Photoredox Catalytic Cascade Radical Addition to Construct 1,4- Diketone-Functionalized Quinoxalin-2(1H)-one Derivatives
Journal ArticleDOI
Remote Radical 1,3-, 1,4-, 1,5-, 1,6- and 1,7-Difunctionalization Reactions
Qiang Zhang,Wei Zhang +1 more
TL;DR: In this article , the radical transformations are used in organic synthesis for the construction of molecular scaffolds and introduction of functional groups, and the resulting radical intermediates can undertake the following paths for the second functionalization: (1) couple with other radical groups, (2) oxidize to cations and then react with nucleophiles, (3) reduce to anions, (4) react with electrophiles, and (5), couple with metal-complexes.
References
More filters
Journal ArticleDOI
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
TL;DR: The conversion of these bench stable, benign catalysts to redox-active species upon irradiation with simple household lightbulbs represents a remarkably chemoselective trigger to induce unique and valuable catalytic processes.
Journal ArticleDOI
Synopsis of some recent tactical application of bioisosteres in drug design.
TL;DR: In this Perspective, some contemporary themes exploring the role of isosteres in drug design are sampled, with an emphasis placed on tactical applications designed to solve the kinds of problems that impinge on compound optimization and the long-term success of drug candidates.
Journal ArticleDOI
Photoredox Catalysis in Organic Chemistry
TL;DR: This Perspective highlights the unique ability of photoredox catalysis to expedite the development of completely new reaction mechanisms, with particular emphasis placed on multicatalytic strategies that enable the construction of challenging carbon-carbon and carbon-heteroatom bonds.
Journal ArticleDOI
Polarity-reversal catalysis of hydrogen-atom abstraction reactions: concepts and applications in organic chemistry
TL;DR: The concept of polarity reversal catalysis (PRC) was introduced in this paper to replace a single-step abstraction, that is slow because of unfavourable polar effects, with a two-step process in which the radicals and substrates are matched.
Journal ArticleDOI
Direct sp3 C–H bond activation adjacent to nitrogen in heterocycles
TL;DR: This tutorial review aims to summarize the key examples of direct functionalization of nitrogen-containing heterocycles via metal-mediated and metal-catalyzed processes, which is meant to serve as a foundation for future investigations into this rapidly developing area of research.