Physiological Approaches to the Control of Oral Biofilms
Philip Marsh,David J. Bradshaw +1 more
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TLDR
Most laboratory and clinical findings support the concept of physiological control, but some data suggest that the ordered structure and metabolically interactive organization of mature dental plaque could generate a community with a high level of homeostasis that is relatively resistant to deliberate external manipulation.Abstract:
Evidence that physiological strategies may be potential routes for oral biofilm control has come from (i) observations of the variations in the intra-oral distribution of members of the resident oral microflora, (ii) changes in plaque composition in health and disease, and (iii) data from laboratory model systems. Key physiological factors that were identified as significant in modulating the microflora included the local pH, redox potential (Eh), and nutrient availability. Increases in mutans streptococci and lactobacilli occur at sites with caries; growth of these species is selectively enhanced at low pH. In contrast, periodontal diseases are associated with plaque accumulation, followed by an inflammatory host response. The increases in Gram-negative, proteolytic, and obligately anaerobic bacteria reflect a low redox potential and a change in nutrient status due to the increased flow of gingival crevicular fluid (GCF). Consequently, physiological strategies for oral biofilm control should focus on red...read more
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Are dental diseases examples of ecological catastrophes
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Oral Microbial Communities: Biofilms, Interactions, and Genetic Systems
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Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples
Nicholas Segata,Susan Kinder Haake,Peter J. Mannon,Katherine P. Lemon,Katherine P. Lemon,Levi Waldron,Dirk Gevers,Curtis Huttenhower,Jacques Izard,Jacques Izard +9 more
TL;DR: The bacterial community composition of ten digestive tract sites from more than 200 normal adults enrolled in the Human Microbiome Project is described, and metagenomically determined metabolic potentials of four representative sites are determined.
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Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration.
TL;DR: Examination of patterns of coaggregation between obligately anaerobic and oxygen-tolerant species that coexist in a model oral microbial community found that F. nucleatum facilitated the survival of obligate anaerobes in aerated environments.
References
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Journal ArticleDOI
Microbial ecology of dental plaque and its significance in health and disease.
TL;DR: It is proposed that disease can be prevented or treated not only by targeting the putative pathogens but also by interfering with the processes that drive the breakdown in homeostasis, and the rate of acid production following sugar intake could be reduced by fluoride, alternative sweeteners, and low concentrations of antimicrobial agents.
Journal ArticleDOI
Biofilms, the customized microniche.
TL;DR: It is clearly, timely to ask the question "What are the essential differences between a planktonic cell growing in the conventional batch culture and a cell of the same species growing in a natural multispecies biofilm?"
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Adhere today, here tomorrow: oral bacterial adherence.
Paul E. Kolenbrander,Jack London +1 more
TL;DR: The characteristics of adhesin and receptor molecules and the potential roles they play in dental plaque accretion are reviewed.
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Bacterial Adhesion to Oral Tissues: A Model for Infectious Diseases
TL;DR: There is evidence which suggests that elevated levels of neuraminidases and proteases associated with poor oral hygiene and gingivitis may also generate cryptitopes which promote colonization of certain Gram-negative bacteria associated with destructive periodontal diseases.