Journal ArticleDOI
Placenta hominis protects osteoporosis in ovariectomized rats.
Han-Jung Chae,K H Choi,Soo-Wan Chae,Hye-Lin Kim,Taekyun Shin,Geun-Youn Lee,G. S. Jeong,H. R. Park,H I Choi,Su-Jin Kim,S. K. Yoo,Hyung-Ryong Kim +11 more
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TLDR
The results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.Abstract:
In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50% from those in sham-operated rats; these decreases were completely inhibited by administration of PHEs for 7 weeks. Osteoclast numbers and the osteoblast surface were enhanced in OVX rats, but PHEs had no effect on these phenomena. Serum phosphorus and alkaline phosphatase in OVX rats increased compared to those in sham-operated rats, but the increases were not affected by the administration of PHEs. Thyroxine (T4) level was stimulated in OVX rats. The extracts inhibited the T4 level in the OVX rats. These results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.read more
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Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats.
TL;DR: Biophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats, and low-magnitude high-frequency MECHVIB is more effective than PEMF on bone healing in terms of relative bone volume.
Journal ArticleDOI
Wnt-Signaling-Mediated Antiosteoporotic Activity of Porcine Placenta Hydrolysates in Ovariectomized Rats
TL;DR: NPPH exerted anti-osteoporotic effects by activating osteogenesis and stimulating Wnt signaling, possibly mediated by the various amino acids and not ovarian hormones.
Journal ArticleDOI
Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth
TL;DR: Evaluated effects of KBS on bone growth suggest that KBS would be helpful to children who are in retard for their age through the elevation of IGF-I.
Journal ArticleDOI
Effects of Hominis placenta on LPS-induced cell toxicity in BV2 microglial cells.
TL;DR: Investigating the effects and signaling pathway of HP in the LPS induced BV2 microglial cells shows that HP has a protective role against LPS stimulation through inhibition of MAPK signaling and suppression of inflammation caused by neurotoxin including LPS.
Journal ArticleDOI
Clinical review of the effects of hominis placental pharmacopuncture in the treatment of facial spasm patients.
TL;DR: Investigating the effect of treatment with Hominis Placental pharmacopuncture for 32 patients with hemifacial spasm suggested that HPP can be useful for treating facial spasm patients.
References
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Journal ArticleDOI
The ovariectomized rat model of postmenopausal bone loss
TL;DR: Ovariectomy induced bone loss in the rat and postmenopausal bone loss share many similar characteristics, including: increased rate of bone turnover with resorption exceeding formation; and initial rapid phase of bone loss followed by a much slower phase.
Journal ArticleDOI
Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium.
TL;DR: Bone mass was measured prospectively in 73 women during the period immediately after menopause and after 2 years of follow-up to assess the protective effects of calcium supplements given alone or combined with low-dosage estrogen therapy.
Journal ArticleDOI
Temporal relationship between bone loss and increased bone turnover in ovariectomized rats
TL;DR: It is indicated that the initial rapid phase of bone loss in OVX rats is coincident with the maximal increase in bone turnover, and at later times postovariectomy, bone loss and bone turnover both subside.
Journal ArticleDOI
Effects of thyroid hormones on bone and mineral metabolism.
TL;DR: It appears that disturbed thyroid function may be involved in the pathogenesis of osteoporosis, one of the major health problems in the western hemisphere.
Journal ArticleDOI
Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats
TL;DR: Results indicate that PTH is a powerful stimulator of bone formation and completely restores lost cancellous bone in osteopenic OVX rats, and the bone anabolic effects of PTH are much more pronounced than those of estrogen or bisphosphonates.
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