Journal ArticleDOI
Placental transport of alcohol and its effect on maternal and fetal acid-base balance.
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TLDR
Serial maternal and Fetal blood sampling during and following the alcohol infusion revealed rapid placental diffusion of alcohol, a highly significant correlation between maternal and fetal blood alcohol concentrations, and a similar peak concentration of approximately 0.230 Gm.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1975-08-01. It has received 79 citations till now. The article focuses on the topics: Acidosis & Metabolic acidosis.read more
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Journal ArticleDOI
Effects on the child of alcohol abuse during pregnancy. Retrospective and prospective studies.
R. Olegård,K.-G. Sabel,M Aronsson,B. Sandin,P. R. Johansson,C. Carlsson,M. Kyllerman,K. Iversen,A. Hrbek +8 more
TL;DR: Investigation of children to alcoholic women gave an incidence of fetal alcohol lesion of one per 300 deliveries of whom half had the complete fetal alcohol syndrome and tracing of alcoholic women during pregnancy and treatment gave favourable effect on intrauterine growth.
Journal ArticleDOI
Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage
TL;DR: A review of the effects of alcohol exposure on the developing brain evaluates results from human, animal andin vitro studies, but focuses on key research issues, including possible mechanisms of damage.
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Alcohol inhibits cell-cell adhesion mediated by human L1.
TL;DR: Because L1 plays a role in both neural development and learning, ethanol inhibition of L1-mediated cell-cell interactions could contribute to FAS and ethanol-associated memory disorders.
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Mutagenic, cancerogenic and teratogenic effects of alcohol.
Günter Obe,Hansjürgen Ristow +1 more
TL;DR: A reduction of cellular RNA synthesis may play an important role in the mutagenic, carcinogenic and teratogenic activity of alcohol.
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Fetal alcohol syndrome: behavioral teratology.
TL;DR: Findings suggest that prenatal exposure to alcohol is associated with a distinct pattern of congenital malformations that have collectively been termed the fetal alcohol syndrome (FAS).
References
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Journal ArticleDOI
Recognition of the fetal alcohol syndrome in early infancy
KennethL. Jones,David W. Smith +1 more
TL;DR: The first necropsy performed on a patient with fetal alcohol syndrome disclosed serious dysmorphogenesis of the brain, which may be responsible for some of the functional abnormalities and the joint malposition seen in this syndrome.
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Effect of alcohol on threatened premature labor.
TL;DR: It is concluded that alcohol can inhibit the uterine activity during labor and that this presumably is due to an inhibition of the release of oxytocin from the neurohypophysis.
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Placental transfer of ethanol.
TL;DR: Placental transfer of 10 per cent ethanol infused at a rate of 15 ml.
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Effect of ethanol upon uterine activity and fetal acid-base state of the rhesus monkey
Terusada Horiguchi,Kotaro Suzuki,Arsenio C. Comas-Urrutia,Eberhard Mueller-Heubach,Ann M. Boyer-Milic,Robert A. Baratz,Hisayo O. Morishima,L. Stanley James,Karlis Adamsons +8 more
TL;DR: Only in animals before term and in which uterine contractions were irregular, partial suppression of labor was observed, and ethanol was ineffective even in cases in which the dose was increased to a level which produced depression of maternal respiration.