Journal ArticleDOI
Plant Anti-cancer Agents and their Biotechnological Production in Plant Cell Biofactories.
Liliana Lalaleo,Abbas Khojasteh,Mohammad Reza Fattahi,Mercedes Bonfill,Rosa M. Cusidó,Javier Palazon +5 more
TLDR
More in-depth studies are required on the biosynthesis of target plant metabolites and its regulation in order to increase their biotechnological production in plant cell factories and ultimately implement these biosustainable processes at an industrial level.Abstract:
Background: Bioactive plant secondary metabolites have complex chemical
structures, which are specific to each plant species/family, and accumulate in tiny amounts
The growing market demand for many phytochemicals can lead to the over-harvesting of
medicinal plants in their natural habitat, endangering species in the process
Objective: An ongoing challenge for our society is therefore to develop a bio-sustainable
production of phytochemicals, among other natural resources Cancer is currently a major
health problem, responsible for approximately 82 million deaths per year worldwide We
therefore focused this review on cancer therapeutic agents from plants and their biotechnological
production
Method and Results: An extensive review of the literature shows that although a wide range
of phytochemicals have demonstrated anti-proliferative activity in vitro, only a few examples
of plant-based drugs are included in the Anatomical Therapeutic Chemical (ATC) classification
as antineoplastic agents These include vinca alkaloids and their derivatives (L01CA),
podophyllotoxin derivatives (L01CB), and paclitaxel and its derivatives (L01CD), as well as
camptothecin derivatives (L01XX) These compounds all have in common a complex chemical
structure, a scarce distribution in nature, and a high added value After describing the
chemical structures, natural sources and biological activities of these anticancer compounds,
we focus on the state of the art in their biotechnological production in plant cell biofactories
Conclusion: More in-depth studies are required on the biosynthesis of target plant metabolites
and its regulation in order to increase their biotechnological production in plant cell factories
and ultimately implement these biosustainable processes at an industrial levelread more
Citations
More filters
Journal ArticleDOI
Plants as sources of natural and recombinant anti-cancer agents.
TL;DR: The anti-cancer agents that are produced by plants naturally or following genetic modification are discussed, and the potential of these products to supply modern healthcare systems is discussed.
Journal ArticleDOI
Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies.
Hendrik Fuchs,Nicole Niesler,Alexandra Trautner,Simko Sama,Gerold Jerz,Hossein Panjideh,Alexander Weng +6 more
TL;DR: A number of strategies that make use of diverse chemicals, cell-penetrating or fusogenic peptides, and light-induced techniques were designed to weaken the membrane integrity of endosomes to overcome the problem of insufficient endosomal escape.
Journal ArticleDOI
Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview.
Li Changxing,Saddia Galani,Faiz-ul Hassan,Zubia Rashid,Muhammad Naveed,Daidong Fang,Asma Ashraf,Wang Qi,Afsheen Arif,Muhammad Saeed,Arif Ali Chishti,Li Jianhua +11 more
TL;DR: This review considers various plant biotechnology approaches used to enhance the production of these anticancer molecules in different species, such as stimulation of suspension culture and hairy roots.
Journal ArticleDOI
Effect of in vitro morphogenesis on the production of podophyllotoxin derivatives in callus cultures of Linum album.
Liliana Lalaleo,Pilar S. Testillano,Maria-Carmen Risueño,Rosa M. Cusidó,Javier Palazon,Rubén Alcázar,Mercedes Bonfill +6 more
TL;DR: The main lignan produced was methoxypodophyllotoxin, whose production was clearly linked to the organogenic capacity of the cell biomass, which to a lesser extent was also the case for podophyLLotoxin.
Book ChapterDOI
Production of the Anticancer Compound Camptothecin in Root and Hairy Root Cultures of Ophiorrhiza mungos L.
TL;DR: In this article, a comparison of 25 different transformed root culture lines of Ophiorrhiza mungos (hairy roots transformed by Agrobacterium rhizogenes), which produce CPT, showed a total CPT content of 890-3200 μg/g dry weight.
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