Polarized light interaction with tissues
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TLDR
The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.Abstract:
This tutorial-review introduces the fundamentals of polarized light interaction with biological tissues and presents some of the recent key polarization optical methods that have made possible the quantitative studies essential for biomedical diagnostics. Tissue structures and the corresponding models showing linear and circular birefringence, dichroism, and chirality are analyzed. As the basis for a quantitative description of the interaction of polarized light with tissues, the theory of polarization transfer in a random medium is used. This theory employs the modified transfer equation for Stokes parameters to predict the polarization properties of single- and multiple-scattered optical fields. The near-order of scatterers in tissues is accounted for to provide an adequate description of tissue polarization properties. Biomedical diagnostic techniques based on polarized light detection, including polarization imaging and spectroscopy, amplitude and intensity light scattering matrix measurements, and polarization-sensitive optical coherence tomography are described. Examples of biomedical applications of these techniques for early diagnostics of cataracts, detection of precancer, and prediction of skin disease are presented. The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.read more
Citations
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Multifunctional materials for implantable and wearable photonic healthcare devices.
Geon-Hui Lee,Geon-Hui Lee,Hanul Moon,Hanul Moon,Hyemin Kim,Gae Hwang Lee,Gae Hwang Lee,Woosung Kwon,Seunghyup Yoo,David Myung,Seok Hyun Yun,Zhenan Bao,Sei Kwang Hahn,Sei Kwang Hahn +13 more
TL;DR: This Review describes emerging multifunctional materials critical to the advent of next-generation implantable and wearable photonic healthcare devices and discusses the path for their clinical translation, along with the future research directions for the field, particularly regarding mobile healthcare and personalized medicine.
Journal ArticleDOI
Polarisation optics for biomedical and clinical applications: a review.
TL;DR: A review of methodologies and applications related to tissue polarimetry, with an emphasis on the adoption of the Stokes-Mueller formalism, is presented in this article, where several recent breakthroughs, development trends, and potential multimodal uses in conjunction with other techniques are also presented.
Journal ArticleDOI
Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications
TL;DR: Polarization sensitive optical coherence tomography (PS-OCT) as mentioned in this paper is an imaging technique based on light scattering that performs rapid two-and three-dimensional imaging of transparent and translucent samples with micrometer scale resolution.
Journal ArticleDOI
Mueller Matrix Polarimetry—An Emerging New Tool for Characterizing the Microstructural Feature of Complex Biological Specimen
TL;DR: The Stokes-Mueller matrix polarimetry (SMMP) as discussed by the authors has been used extensively in biomedical applications, such as biomedical studies and clinical diagnosis, to characterize the anisotropic optical properties of complex biomedical specimens.
Journal ArticleDOI
Measurement of tissue optical properties in the context of tissue optical clearing
Alexey N. Bashkatov,K. V. Berezin,Konstantin N. Dvoretskiy,Maria L. Chernavina,Elina A. Genina,Elina A. Genina,Vadim D. Genin,V. I. Kochubey,V. I. Kochubey,Ekaterina N. Lazareva,Ekaterina N. Lazareva,Ekaterina N. Lazareva,Alexander B. Pravdin,Marina E. Shvachkina,Polina A. Timoshina,Polina A. Timoshina,Daria K. Tuchina,Daria K. Tuchina,Dmitry D. Yakovlev,Dmitry A. Yakovlev,Irina Yu. Yanina,Irina Yu. Yanina,Olga S. Zhernovaya,Valery V. Tuchin,Valery V. Tuchin,Valery V. Tuchin +25 more
TL;DR: An overview of recent results on the measurements and control of tissue optical properties is presented, including a brief review of optical properties of biological tissues and efficacy of optical clearing method in application to monitoring of diabetic complications and visualization of blood vessels and microcirculation.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
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Light Scattering by Small Particles
TL;DR: Light scattering by small particles as mentioned in this paper, Light scattering by Small Particle Scattering (LPS), Light scattering with small particles (LSC), Light Scattering by Small Parts (LSP),
Journal ArticleDOI
Optical Coherence Tomography
TL;DR: The optical coherence tomograph is a new, noninvasive technical device that can obtain cross-sectional, high-resolution images-optical coherencetomographs (OCT)-of the retina that permits an accurate evaluation of various macular and chorioretinal pathologies and the early detection of glaucomatous damage.
Journal ArticleDOI
Optical properties of biological tissues: a review.
TL;DR: A review of reported tissue optical properties summarizes the wavelength-dependent behavior of scattering and absorption in cells and tissues.
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