Patent
Polymerized solid lipid nanoparticles for oral or mucosal delivery of therapeutic proteins and peptides
TLDR
In this paper, the use of modified lipid nano/micro particles for the oral delivery of drugs and antigen delivery systems is described, which have been modified, preferably on their surface, to contain a molecule or ligand, which targets the nano-micro particles to a specific site.Abstract:
The present invention encompasses lipid nano/micro particles, which have been modified, preferably on their surface, to contain a molecule or ligand, which targets the nano/micro particles to a specific site. The invention also encompasses the use of the modified lipid nano/micro particles for the oral delivery of drugs and antigen delivery systems.read more
Citations
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Journal ArticleDOI
Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials
Tanira Aguirre,Desirée Teijeiro-Osorio,Mónica Rosa,Ivan Coulter,María J. Alonso,David J. Brayden +5 more
TL;DR: The conclusion is that most of the technologies in clinical trials are incremental rather than paradigm-shifting and that even the more clinically advanced oral peptide drugs examples of oral bioavailability appear to yield Oral bioavailability values of only 1-2% and are, therefore, only currently suitable for a limited range of peptides.
Journal ArticleDOI
Solid lipid nanoparticles: an oral bioavailability enhancer vehicle.
TL;DR: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT, and make SLNs a potential BA enhancer vehicle for various Class II, III and IV drugs.
Journal ArticleDOI
Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery
TL;DR: This review highlights the simple and easily scaled-up novel SLN and NLC along with their different production techniques, hurdles, and strategies for the production of LNs, characterization, lyophilization and drug release and summarizes the research findings reported by the different researchers regarding the different method of preparation, excipients and their significant findings.
Journal ArticleDOI
Solid lipid nanoparticles: a review on recent perspectives and patents.
TL;DR: In this review, the authors have covered areas from the basic introduction of SLNs to its applications in controlled drug delivery and patents disclosed related to the SLNs for the period 2014–2019.
Patent
Lipid nanoparticle capsules
TL;DR: In this paper, a delivery system for active ingredients which comprises lipid nanoparticles, such as solid-lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC), polymerically coated, and their use in the preparation of pharmaceutical, cosmetic and/or alimentary compositions.
References
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Journal ArticleDOI
Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin.
TL;DR: It is demonstrated that SLNs and WGA-modified SLNs promoted the oral absorption of insulin and protected insulin against degradation by digestive enzymes in vitro.
Patent
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
Hongming Chen,Robert Langer +1 more
TL;DR: In this paper, targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics are presented, which have been modified on their surface to contain a molecule or ligand which targets the polymerized polymeric liposome to a specific site or cell type.
Journal ArticleDOI
Investigation of lectin-modified insulin liposomes as carriers for oral administration.
TL;DR: Results confirmed that lectin-modified liposomes promote the oral absorption of insulin due to the specific-site combination on GI cell membrane.
Patent
Membrane scaffold proteins
Stephen G. Sligar,Timothy H. Bayburt,Mary A. Schuler,Natanya R. Civjan,Yelena V. Grinkova,Ilia G. Denisov,Stephen J. Grimme +6 more
TL;DR: In the presence of phospholipid, Membrane scaffold proteins (MSPs) as discussed by the authors form nanoscopic bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain.
Patent
Functionalized solid lipid nanoparticles and methods of making and using same
TL;DR: In this paper, the authors proposed functionalized solid lipid nanoparticles comprising a neutral lipid and a first functionalized polymer comprising at least one ionic or ionizable moiety and methods for providing same.