Journal ArticleDOI
Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
Stanley Zammit,G. Jones,Susan J. Jones,Nadine Norton,R. D. Sanders,Charis Milham,Geraldine McCarthy,Lisa Jones,Alastair G. Cardno,M. Y. Gray,Kieran C. Murphy,Michael Conlon O'Donovan,Michael John Owen +12 more
TLDR
These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.Abstract:
Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.read more
Citations
More filters
Journal ArticleDOI
Toward Constructing an Endophenotype Strategy for Bipolar Disorders
TL;DR: A strategy constructed to improve the phenotypic definition of bipolar disorder by elucidating candidate endophenotypes is presented and studies to evaluate candidateEndophenotypes with respect to specificity, heritability, temporal stability, and prevalence in unaffected relatives are encouraged.
Journal ArticleDOI
Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.
TL;DR: There is small but significant relationship between Val158Met genotype and executive function in healthy individuals but not in schizophrenia, and it is suggested that Val and Met alleles are codominant in their effects on cognition.
Journal ArticleDOI
Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression
TL;DR: Current evidence does not support the use of such genes to predict dangerousness or as markers for therapeutic interventions, and no association between any polymorphism analyzed and aggression is found.
Journal ArticleDOI
Effects of COMT polymorphisms on brain function and behavior in health and disease
A. Veronica Witte,Agnes Flöel +1 more
TL;DR: Future studies should try to disentangle the complex effects of COMT Val158Met on brain functions by taking gender, age, ethnicity, endophenotypes, as well as gene-environment and gene-gene interactions into account.
Journal ArticleDOI
Pathways to Aggression in Schizophrenia Affect Results of Treatment
Jan Volavka,Leslie Citrome +1 more
TL;DR: In this paper, the authors review pathways that may lead to the development of aggressive behavior in patients with schizophrenia and discuss their impact on treatment and discuss the impact of these pathways on treatment.
References
More filters
Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
TL;DR: In this paper, a large sample of male children from birth to adulthood was studied to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not.
Journal ArticleDOI
The Overt Aggression Scale for the objective rating of verbal and physical aggression.
TL;DR: The authors describe the design and reliability of a rating scale that measures aggressive behaviors in adults and children and the clinical and research applications of this scale are discussed.
Journal ArticleDOI
Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior
TL;DR: It is found that schizophrenic patients who are homozygous for the low activity allele were judged by their psychiatrists to be at higher risk for aggressive and dangerous behavior than those who were homozygously for the high activity allele.
Journal ArticleDOI
Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder.
TL;DR: The gene determining the activity of an important regulatory enzyme in catecholamine inactivation is associated with violent behavior in patients with schizophrenia and schizoaffective disorder.