Journal ArticleDOI
Possible involvement of myeloperoxidase in lipid peroxidation
TLDR
The MPO-H2O2 system oxidizes mildly LDL but in the presence of chloride a propagation phase, with a rapid increase of conjugated diene formation, was observed and indicates involvement of MPO in the process.About:
This article is published in International Journal of Biochemistry.The article was published on 1992-01-01. It has received 87 citations till now. The article focuses on the topics: Lipid peroxidation & Malondialdehyde.read more
Citations
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Journal ArticleDOI
Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
TL;DR: Findings identify myeloperoxidase as a component of human vascular lesions and suggest that this heme protein can generate reactive species that damage lipids and proteins may contribute to atherogenesis by catalyzing oxidative reactions in the vascular wall.
Journal ArticleDOI
Kinetics of Oxidation of Tyrosine and Dityrosine by Myeloperoxidase Compounds I and II IMPLICATIONS FOR LIPOPROTEIN PEROXIDATION STUDIES
Leah A. Marquez,H. Brian Dunford +1 more
TL;DR: In this paper, transient spectral and kinetic measurements were performed to study the oxidation of tyrosine by the myeloperoxidase intermediates, compounds I and II, using both sequential mixing and single-mixing stopped-flow techniques.
Journal ArticleDOI
Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.
TL;DR: Particular emphasis is placed on the reactions of the reactive species generated by this enzyme, the mechanisms and sites of damage, the role of modification of the different components of low-density lipoprotein, and the biological consequences of such oxidation on cell types present in the artery wall and in the circulation.
Journal ArticleDOI
Role of Arterial Wall Antioxidant Defense in Beneficial Effects of Exercise on Atherosclerosis in Mice
TL;DR: The results indicate that exercise-induced plasma oxidative stress could be responsible for the prevention of atherosclerosis by stimulating arterial antioxidant response and vitamin E supplementation could be deleterious in exercisers by inhibiting antioxidant enzyme buildup in the arterial wall.
References
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Journal ArticleDOI
Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems.
TL;DR: Alkaline pyridine-butanol mixture dissolves both proteins and lipids that are precipitated or opalescent during the reaction, yielding a more accurate MDA estimation as well as simplifying the procedure.
Journal ArticleDOI
Continuous monitoring of in vitro oxidation of human low density lipoprotein.
TL;DR: The kinetics of the oxidation of human low densit) lipoprotein (LDL) can be measured continuously by monitoring the change of the 234 nm diene absorption as discussed by the authors.
Journal ArticleDOI
Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation XXV. RECONSTITUTION OF VESICLES CATALYZING 32Pi—ADENOSINE TRIPHOSPHATE EXCHANGE
Yasuo Kagawa,Efraim Racker +1 more
TL;DR: It was shown that the reconstitution of vesicular structures with functional activity required several hours and that the formation of new vesicles from solubilized P-lipids was obtained by demonstrating inclusion of macromolecules such as 14C-labeled inulin or ferritin which could not be removed by washing.
Journal ArticleDOI
Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes.
TL;DR: It is concluded that considerable amounts of biologically reactive carbonyl derivatives are released in lipid peroxidation and yet may not be picked up by the thiobarbituric acid reaction.
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