Potassium accumulation in interstitial space during epileptiform seizures
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TLDR
There is an increase in the concentration of potassium in the interstitial space during seizures, and a model is proposed in which this potassium accumulation is an important step in the regenerative, all-or-none-aspect of the initiation of seizures.About:
This article is published in Experimental Neurology.The article was published on 1970-03-01 and is currently open access. It has received 211 citations till now. The article focuses on the topics: Water flow & Potassium.read more
Citations
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Journal ArticleDOI
Multistability in a neuron model with extracellular potassium dynamics
Xing-Xing Wu,Jianwei Shuai +1 more
TL;DR: It is shown that, besides hyperexcitability and bursting pattern modulation, the potassium dynamics can induce not only bistability but also tristability of different firing patterns and the emergence of the complex behavior of multistability due to the dynamical [K{+}]{o} modulation on neuronal activities.
Journal ArticleDOI
Spiking patterns of a neuron model to stimulus: Rich dynamics and oxygen's role
TL;DR: Investigation in detail of stimulus-induced spiking patterns in a biologically plausible neuron model in which the oxygen concentration and the dynamical concentrations of potassium, sodium, and chloride are considered reveals that the stimulus can induce two different phase transitions from the SD state to the SZ state according to the phase transition theory, which results in the different electrical activities.
Book ChapterDOI
Pharmacology of the brain: the hippocampus, learning and seizures.
TL;DR: The hippocampus has since long been a favorite target of anatomical and physiological studies of cortical properties, and the general electrophysiological properties of its main neuronal type, the pyramidal cell, have been well studied.
Journal ArticleDOI
Enhancement during REM sleep of extracellular potassium ion activity in the reticular formation.
Journal ArticleDOI
Epilepsy and adenosinetriphosphate (ATP): Effect of electrical stimulation and high potassium perfusion on hippocampal ATP contents
E.S. Marichich,A.G. Nasello +1 more
TL;DR: The results indicate that the relation between hippocampal ATP levels and the genesis of seizures is not a specific one, but rather that ATP levels may fall simply as a consequence of enhanced electrical activity.
References
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Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.
TL;DR: In the central nervous system of the leech, which contains smooth muscle cells in its connective tissue capsule, the effect of massive neuronal activity on the resting potential of glial cells could not be studied adequately because the preparation under these conditions dislodged the electrode.
Journal ArticleDOI
Cortical cellular phenomena in experimental epilepsy: interictal manifestations.
H. Matsumoto,C A Marsan +1 more
TL;DR: An intracellular analysis from the involved elements was carried out during the development and course of the organized rhythmical electrographic seizures simultaneously monitored with surface electrodes, finding that some neurons appear to be activated only in the later phases of the seizure.
Journal ArticleDOI
The after-effects of impulses in the giant nerve fibres of Loligo
B. Frankenhaeuser,A. L. Hodgkin +1 more
TL;DR: Reducing the concentrations of calcium and magnesium made the giant axon of Loligo spontaneously active and formed long trains of impulses in response to a single shock.
Journal ArticleDOI
Relations between EEG phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity.
TL;DR: Possible mechanisms relating EEG waves to cellular potentials are discussed within the framework of transcortical and soma-apical dendrite potential distributions during different phases of physiological and pathological cortical activity.