Potassium accumulation in interstitial space during epileptiform seizures
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TLDR
There is an increase in the concentration of potassium in the interstitial space during seizures, and a model is proposed in which this potassium accumulation is an important step in the regenerative, all-or-none-aspect of the initiation of seizures.About:
This article is published in Experimental Neurology.The article was published on 1970-03-01 and is currently open access. It has received 211 citations till now. The article focuses on the topics: Water flow & Potassium.read more
Citations
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Ionic dynamics mediate spontaneous termination of seizures and postictal depression state.
Giri P. Krishnan,Maxim Bazhenov +1 more
TL;DR: Using a realistic computational model, it is demonstrated that termination of seizure and postictal depression state may be mediated by dynamics of the intracellular and extracellular ion concentrations.
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The relationship between interictal and ictal paroxysms in an in vitro model of focal hippocampal epilepsy.
TL;DR: Exposure of preparations showing electrical seizures to blockers of synaptic transmission or to cholinergic agonists abolished interictal spiking in all hippocampal fields but did not impede the initiation of ictal episodes in area CA1.
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Neuronal and glial membrane potentials during sleep and paroxysmal oscillations in the neocortex.
Florin Amzica,Mircea Steriade +1 more
TL;DR: It is proposed that the mechanisms underlying the neuron–glia communication include, besides the traditional neurotransmitter- and ion-mediated pathways, field effects crossing their membranes as a function of the state of the cortical network.
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Termination of Epileptic Afterdischarge in the Hippocampus
TL;DR: It is hypothesized that [K+]o lost by the intensely discharging neurons during the afterdischarge triggers propagating waves of depolarization in the astrocytic network, which induces a depolarizing block of spike generation in neurons, resulting in “postictal depression” of the EEG.
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The Role of Extracellular Potassium in Hippocampal Epilepsy
TL;DR: Investigating changes in extracellular potassium concentration during focal hippocampal epilepsy using potassium-sensitive microelectrodes observed that interictal K+ responses in hippocampus lasted longer and had slower rise times, and that peak interictAL and ictal [K+]o values were consistently lower.
References
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Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.
TL;DR: In the central nervous system of the leech, which contains smooth muscle cells in its connective tissue capsule, the effect of massive neuronal activity on the resting potential of glial cells could not be studied adequately because the preparation under these conditions dislodged the electrode.
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Cortical cellular phenomena in experimental epilepsy: interictal manifestations.
H. Matsumoto,C A Marsan +1 more
TL;DR: An intracellular analysis from the involved elements was carried out during the development and course of the organized rhythmical electrographic seizures simultaneously monitored with surface electrodes, finding that some neurons appear to be activated only in the later phases of the seizure.
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The after-effects of impulses in the giant nerve fibres of Loligo
B. Frankenhaeuser,A. L. Hodgkin +1 more
TL;DR: Reducing the concentrations of calcium and magnesium made the giant axon of Loligo spontaneously active and formed long trains of impulses in response to a single shock.
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Relations between EEG phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity.
TL;DR: Possible mechanisms relating EEG waves to cellular potentials are discussed within the framework of transcortical and soma-apical dendrite potential distributions during different phases of physiological and pathological cortical activity.