Potassium accumulation in interstitial space during epileptiform seizures
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TLDR
There is an increase in the concentration of potassium in the interstitial space during seizures, and a model is proposed in which this potassium accumulation is an important step in the regenerative, all-or-none-aspect of the initiation of seizures.About:
This article is published in Experimental Neurology.The article was published on 1970-03-01 and is currently open access. It has received 211 citations till now. The article focuses on the topics: Water flow & Potassium.read more
Citations
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Journal ArticleDOI
Hippocampal physiology: Experiments on regulation of its electrical activity, on the mechanism of seizures, and on a hypothesis of learning
TL;DR: A review is made of experiments which show that hippocampal electrical activity is dependent on synaptic facilitation and regulated by extracellular potassium levels, and the relationship this has to hippocampal seizures, and a hypothesis on the role of the hippocampus in learning is considered.
Journal ArticleDOI
The hippocampus and learning
TL;DR: The hippocampus and learning: the physiological approach and a hypothesis on the role of hippocampal potassium in information processing relevant to learning are presented.
Journal ArticleDOI
Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex.
Paolo Bazzigaluppi,Paolo Bazzigaluppi,Iliya Weisspapir,Bojana Stefanovic,Luc Leybaert,Peter L. Carlen +5 more
TL;DR: It is shown for the first in vivo demonstration that astrocytic GJs are major determinants for the spatial buffering of [K+]o and that an increase in K+o alone does not trigger seizures in the neocortex.
Book ChapterDOI
Extracellular Potassium Dynamics and Epileptogenesis
TL;DR: This chapter describes how recent computational models of cortical circuits with extracellular potassium concentration ([K+)o) dynamics help to overcome the limitations in the understanding of mechanistic understanding of ion concentration dynamics and epileptogenesis, and contribute towards a more refined and experimentally testable theory of [K+]o dynamics and epilepsy.
Journal ArticleDOI
Computational model of interictal discharges triggered by interneurons.
TL;DR: It was revealed that short-term synaptic depression is a crucial factor in ceasing each of the discharges, and it also determines their durations and frequencies.
References
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TL;DR: In the central nervous system of the leech, which contains smooth muscle cells in its connective tissue capsule, the effect of massive neuronal activity on the resting potential of glial cells could not be studied adequately because the preparation under these conditions dislodged the electrode.
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Cortical cellular phenomena in experimental epilepsy: interictal manifestations.
H. Matsumoto,C A Marsan +1 more
TL;DR: An intracellular analysis from the involved elements was carried out during the development and course of the organized rhythmical electrographic seizures simultaneously monitored with surface electrodes, finding that some neurons appear to be activated only in the later phases of the seizure.
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The after-effects of impulses in the giant nerve fibres of Loligo
B. Frankenhaeuser,A. L. Hodgkin +1 more
TL;DR: Reducing the concentrations of calcium and magnesium made the giant axon of Loligo spontaneously active and formed long trains of impulses in response to a single shock.
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Relations between EEG phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity.
TL;DR: Possible mechanisms relating EEG waves to cellular potentials are discussed within the framework of transcortical and soma-apical dendrite potential distributions during different phases of physiological and pathological cortical activity.