Journal ArticleDOI
Potassium phthalimide-N-oxyl: a novel, efficient, and simple organocatalyst for the one-pot three-component synthesis of various 2-amino-4H-chromene derivatives in water
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TLDR
In this article, a wide variety of 2-amino-4H-chromene derivatives with diverse substituents on the 4Hchromene ring were efficiently prepared via one-pot, three-component reaction of an aromatic aldehyde, malononitrile (or ethyl cyanoacetate), and diverse enolizable C-H activated acidic compounds in the presence of low loading of potassium phthalimide-N-oxyl (POPINO), as a new organocatalyst, in aqueous media.About:
This article is published in Tetrahedron.The article was published on 2013-01-21. It has received 238 citations till now. The article focuses on the topics: Potassium phthalimide & Malononitrile.read more
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Meglumine: A novel and efficient catalyst for one-pot, three-component combinatorial synthesis of functionalized 2-amino-4H-pyrans.
TL;DR: An efficient one-pot synthesis of functionalized 2-amino-4H-pyrans by a meglumine-catalyzed three-component reaction has been developed and provides an alternative approach for rapid access to construct a diversity-oriented library of 4H- pyrans.
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A green one-pot three-component synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives using a Fe3O4@SiO2–imid–PMAn magnetic nanocatalyst under ultrasonic irradiation or reflux conditions
TL;DR: An efficient and environmentally benign procedure for the synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives has been developed by a one-pot three-component reaction of various aldehydes, malononitrile, and dimedone or hydroxycoumarin in the presence of Fe3O4@SiO2-imid-PMAn nanoparticles as magnetic catalysts under ultrasonic irradiation or reflux conditions in water as mentioned in this paper.
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Highly efficient organocatalytic synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans under mechanochemical ball milling
TL;DR: An improved one-pot three-component approach for the synthesis of a wide range of densely functionalized 2-amino-3-cyano-4H-pyran annulated derivatives has been described by the reaction of aryl aldehydes, malononitrile and diverse electron-rich phenolic or enolizable carbonyl compounds under mechanochemical ball milling conditions in the presence of potassium phthalimide (POPI), as a mild basic organocatalyst, at ambient temperature as discussed by the authors.
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Ultrasonic-assisted preparation of nano eggshell powder: a novel catalyst in green and high efficient synthesis of 2-aminochromenes.
TL;DR: The nano eggshell powder has been prepared by ultrasound irradiation and used as a novel and biodegradable catalyst with high catalytic activity and reusability in green synthesis of 2-aminochromenes via condensation of α- or β-phathol, malononitrile and aromatic aldehydes at 120 °C under solvent-free conditions.
Journal ArticleDOI
Synthesis and applications of CoFe2O4 nanoparticles for multicomponent reactions
TL;DR: An efficient, simple, green protocol is developed for the synthesis of 2-amino-4-(phenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile derivatives and 2,2′-arylmethylene bis(3-hydroxy-5,5-dimmethyl-2-cyclohexene-1-one) derivatives in the presence of CoFe2O4 nanoparticles in aqueous ethanol medium.
References
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Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
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Hydrophobic acceleration of Diels-Alder reactions
Darryl Rideout,Ronald Breslow +1 more
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Strategies for Innovation in Multicomponent Reaction Design
TL;DR: This Account provides several examples that illustrate the use of SRR with known MCRs as starting points for synthetic innovation in this area, and explores strategies for engineering improvements into known M CRs, either by increasing the dimensionality, broadening the scope of useful input structures, or both.
Journal ArticleDOI
Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives
TL;DR: In this article, the synthesis and biological activity of heterocyclic compounds synthesized by carbon suboxide was investigated and some 2-oxo (2H) 1-benzopyran-3-carboxamide derivatives were screened.