Predictors of refractoriness to therapy and healthcare resource utilization in 378 patients with primary autoimmune hemolytic anemia from eight Italian reference centers
Wilma Barcellini,Anna Zaninoni,Bruno Fattizzo,Juri Alessandro Giannotta,Monia Lunghi,Antonella Ferrari,Anna Paola Leporace,Nilla Maschio,Laura Scaramucci,Silvia Cantoni,Federico Chiurazzi,Dario Consonni,Giuseppe Rossi,Paolo de Fabritiis,Gianluca Gaidano,Alberto Zanella,Agostino Cortelezzi,Agostino Cortelezzi +17 more
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TLDR
A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER and the experience of the Oklahoma registry and the blood Center of Wisconsin shows promising results.Abstract:
REFERENCES 1. Al-Nouri ZL, Reese JA, Terrell DR, Vesely SK, George JN. Drug-induced thrombotic microangiopathy: a systematic review of published reports. Blood. 2015;125:616-618. 2. Reese JA, Bougie DW, Curtis BR, et al. Drug-induced thrombotic microangiopathy: experience of the Oklahoma registry and the blood Center of Wisconsin. Am J Hematol. 2015;90:406-410. 3. Miller PJ, Farland AM, Knovich MA, Batt KM, Owen J. Successful treatment of intravenously abused oral Opana ER-induced thrombotic microangiopathy without plasma exchange. Am J Hematol. 2014;89: 695-697. 4. Hunt R, Yalamanoglu A, Tumlin J, et al. A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER. Blood. 2017;129:896-905. 5. Yui JC, Dispenzieri A, Leung N. Ixazomib-induced thrombotic microangiopathy. Am J Hematol. 2017;92:E53-E55. 6. George JN, Morton JM, Liles NW, Nester CM. After the party's over. N Engl J Med. 2017;371:74-80.read more
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Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting
Ulrich Jäger,Wilma Barcellini,Catherine Broome,Morie A. Gertz,Anita Hill,Quentin A. Hill,Bernd Jilma,David J. Kuter,Marc Michel,Marco Montillo,Alexander Röth,Sacha Zeerleder,Sigbjørn Berentsen +12 more
TL;DR: The First International Consensus Group recommended that Corticosteroids remain first-line therapy for warm-AIHA, while the addition of rituximab should be considered early in severe cases and if no prompt response to steroids is achieved.
Journal ArticleDOI
Cold agglutinin disease revisited: a multinational, observational study of 232 patients
Sigbjørn Berentsen,Wilma Barcellini,Shirley D'Sa,Ulla Randen,Tor Henrik Anderson Tvedt,Bruno Fattizzo,Einar Haukås,Megan Kell,Robert Brudevold,Anders E.A. Dahm,Anders E.A. Dahm,Jakob Dalgaard,Hege Frøen,Randi Fykse Hallstensen,Pernille H. Jæger,Henrik Hjorth-Hansen,Agnieszka Malecka,Agnieszka Malecka,Markku Oksman,Jürgen Rolke,Mallika Sekhar,Jon Hjalmar Sørbø,Eirik Brekka Tjønnfjord,Galina Tsykunova,Geir E. Tjønnfjord +24 more
TL;DR: In patients responding to rituximab-bendamustine, median response duration was not reached after 88 months, and estimated 5-year sustained remission was 77%.
Journal ArticleDOI
The Changing Landscape of Autoimmune Hemolytic Anemia
TL;DR: On the whole, the double-edged sword of new pathogenetic insights and therapies has changed the landscape of AIHA, both providing enthusiastic knowledge and complicating the clinical management of this disease.
Journal ArticleDOI
New Insights in Autoimmune Hemolytic Anemia: From Pathogenesis to Therapy Stage 1.
TL;DR: A comprehensive review of the main clinical characteristics, diagnosis, and pathogenic mechanisms of AIHA are provided, along with classic and new therapeutic approaches.
Journal ArticleDOI
How I treat warm autoimmune hemolytic anemia.
Wilma Barcellini,Bruno Fattizzo +1 more
TL;DR: Warm autoimmune hemolytic anemia (wAIHA) is caused by increased erythrocyte destruction by immunoglobulin G (IgG) autoantibodies, with or without complement activation as discussed by the authors.
References
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Journal ArticleDOI
Drug-induced thrombotic microangiopathy: a systematic review of published reports
TL;DR: Criteria to assess the strength of evidence for a causal association of a drug with TMA is established and data can provide support for clinicians evaluating patients with suspected TMA.
Journal ArticleDOI
Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients.
Wilma Barcellini,Bruno Fattizzo,Anna Zaninoni,Tommaso Radice,Ilaria Nichele,Eros Di Bona,Monia Lunghi,C Tassinari,Fiorella Alfinito,Antonella Ferrari,Anna Paola Leporace,Pasquale Niscola,Monica Carpenedo,Carla Boschetti,Nicoletta Revelli,Maria Antonietta Villa,Dario Consonni,Laura Scaramucci,Paolo de Fabritiis,Giuseppe Tagariello,Gianluca Gaidano,Francesco Rodeghiero,Agostino Cortelezzi,Alberto Zanella +23 more
TL;DR: Predictors of a fatal outcome were severe infections, particularly in splenectomized cases, acute renal failure, Evans syndrome, and multitreatment (4 or more lines).
Journal ArticleDOI
How I treat autoimmune hemolytic anemia
TL;DR: The parameters present in diagnostic testing that allow for prognostic insight and present algorithms for both diagnosis and treatment of the AIHA patient in diverse situations are reviewed in the hope that this review may offer guidance in regard to personalized therapy recommendations.
Journal ArticleDOI
Splenectomy for Immune Thrombocytopenia: Down but not out
TL;DR: Avoid splenectomy within the first 12 months after ITP diagnosis for most patients to allow for spontaneous or therapy-induced remissions, particularly in older patients who have increased surgical morbidity and lower rates of response, and in young children.
Journal ArticleDOI
How I manage patients with cold agglutinin disease.
TL;DR: Therapies targeting the classical complement pathway are promising, and the complement C1s inhibitor, BIVV009, has shown favourable results in preliminary studies.
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Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients.
Wilma Barcellini,Bruno Fattizzo,Anna Zaninoni,Tommaso Radice,Ilaria Nichele,Eros Di Bona,Monia Lunghi,C Tassinari,Fiorella Alfinito,Antonella Ferrari,Anna Paola Leporace,Pasquale Niscola,Monica Carpenedo,Carla Boschetti,Nicoletta Revelli,Maria Antonietta Villa,Dario Consonni,Laura Scaramucci,Paolo de Fabritiis,Giuseppe Tagariello,Gianluca Gaidano,Francesco Rodeghiero,Agostino Cortelezzi,Alberto Zanella +23 more