Preeclampsia and Gestational Hypertension Are Associated With Childhood Blood Pressure Independently of Family Adiposity Measures The Avon Longitudinal Study of Parents and Children
J. J. Miranda Geelhoed,Abigail Fraser,Kate Tilling,Li Benfield,George Davey Smith,Naveed Sattar,Scott M. Nelson,Debbie A Lawlor +7 more
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TLDR
The association of preeclampsia with offspring systolic and diastolic blood pressures attenuated toward the null with further adjustment for birth weight and gestational age, whereas these adjustments did not attenuate the association of gestational hypertension with offspring blood pressure.Abstract:
Background—Offspring of women with hypertensive disorders of pregnancy are at increased risk of cardiovascular complications later in life, but the mechanisms underlying these associations are unclear. Our aim was to examine whether adjusting for birth weight and familial adiposity changed the association of hypertensive disorders of pregnancy with offspring blood pressure. Methods and Results—Using data from 6343 nine-year-old participants in the Avon Longitudinal Study of Parents and Children, we examined the association between hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) and offspring blood pressure. Both preeclampsia and gestational hypertension were associated with systolic and diastolic blood pressures in the 9-year-old offspring; after adjustment for parental and own adiposity and for other potential confounders, the mean difference in systolic blood pressure was 2.05 mm Hg (95 confidence interval, 0.72 to 3.38) and 2.04 mm Hg (95 confidence interval, 1.42 to 2.6...read more
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Journal ArticleDOI
Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Abigail Fraser,Corrie Macdonald-Wallis,Kate Tilling,Andy Boyd,Jean Golding,George Davey Smith,John Henderson,John Macleod,Lynn Molloy,Andy R Ness,S M Ring,Scott M. Nelson,Debbie A Lawlor +12 more
TL;DR: The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children.
Journal ArticleDOI
Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review.
Esther F. Davis,Merzaka Lazdam,Adam J. Lewandowski,Stephanie Worton,Brenda Kelly,Yvonne Kenworthy,Satish Adwani,Andrew R. Wilkinson,Kenny McCormick,Ian L. Sargent,Christopher W.G. Redman,Paul Leeson +11 more
TL;DR: Young offspring of pregnancies complicated by preeclampsia already have increased blood pressure and BMI, a finding that may need to be considered in future primary prevention strategies for cardiovascular disease.
Journal ArticleDOI
Fetal Programming and Metabolic Syndrome
Paolo Rinaudo,Erica Wang +1 more
TL;DR: The epidemiological evidence linking prenatal stress, manifested by low birth weight, to metabolic syndrome and its individual components is summarized and potential mechanisms for the long-term effects of fetal reprogramming are suggested.
Journal ArticleDOI
Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy The Generation R Study
Romy Gaillard,Eric A.P. Steegers,Liesbeth Duijts,Janine F. Felix,Albert Hofman,Oscar H. Franco,Vincent W. V. Jaddoe +6 more
TL;DR: In this article, the associations of both maternal and paternal prepregnancy body mass index (BMI) with childhood body fat distribution and cardiometabolic outcomes and explored whether any association was explained by pregnancy, birth, and childhood factors.
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Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease
TL;DR: Evidence is summarized on the cardiovascular effects of fetal growth restriction, from subcellular to organ structure and function as well as from fetal to early postnatal life, to clarify whether and how early life cardiovascular remodeling persists into adulthood and determines the increased cardiovascular mortality rate described in epidemiologic studies.
References
More filters
Journal ArticleDOI
The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations.
Reuben M. Baron,David A. Kenny +1 more
TL;DR: This article seeks to make theorists and researchers aware of the importance of not using the terms moderator and mediator interchangeably by carefully elaborating the many ways in which moderators and mediators differ, and delineates the conceptual and strategic implications of making use of such distinctions with regard to a wide range of phenomena.
Journal ArticleDOI
Establishing a standard definition for child overweight and obesity worldwide: international survey
TL;DR: The proposed cut off points, which are less arbitrary and more internationally based than current alternatives, should help to provide internationally comparable prevalence rates of overweight and obesity in children.
Journal ArticleDOI
ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology.
TL;DR: The comprehensiveness of the ALSPAC approach with a total population sample unselected by disease status, and the availability of parental genotypes, provides an adequate sample for statistical analysis and for avoiding spurious results.
Journal ArticleDOI
The classification and definition of the hypertensive disorders of pregnancy.
D. A. Davey,Ian MacGillivray +1 more
TL;DR: It is hoped that this clinical classification and associated definitions will find general acceptance so that the incidence and outcome of the hypertensive disorders of pregnancy and the results of research in different centers may be compared and mutual understanding achieved.
Journal ArticleDOI
Diagnosis and management of gestational hypertension and preeclampsia.
TL;DR: There is an urgent need to conduct randomized trials to determine the efficacy and safety of antihypertensive drugs in women with mild hypertension-preeclampsia and the benefits and risks of magnesium sulfate during labor and postpartum in Women with mild preeClampsia.