Journal ArticleDOI
Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis.
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TLDR
There is no evidence of an increased risk for major malformations when metformin is taken during the first trimester of pregnancy, on the basis of the limited data available today.About:
This article is published in Fertility and Sterility.The article was published on 2006-09-01. It has received 216 citations till now. The article focuses on the topics: Metformin & Polycystic ovary.read more
Citations
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Journal ArticleDOI
Metformin versus Insulin for the Treatment of Gestational Diabetes
TL;DR: In women with gestational diabetes mellitus, metformin (alone or with supplemental insulin) is not associated with increased perinatal complications as compared with insulin.
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The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care#
Moshe Hod,Anil Kapur,David A. Sacks,Eran Hadar,Eran Hadar,Mukesh M. Agarwal,Gian Carlo Di Renzo,Luis Cabero Roura,Harold David McIntyre,Jessica L. Morris,Hema Divakar +10 more
TL;DR: In addition to the FIGO Executive Board, all relevant FIGO Committees and Working Groups contributed to and supported the document.
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Metformin: an old but still the best treatment for type 2 diabetes
TL;DR: The role of metformin in the treatment of patients with type 2 diabetes is reviewed, its potential role for a variety of insulin resistant and pre-diabetic states, obesity, metabolic abnormalities associated with HIV disease, gestational diabetes, cancer, and neuroprotection are discussed.
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Diabetes and pregnancy: an endocrine society clinical practice guideline
Ian Blumer,Eran Hadar,David R. Hadden,Lois Jovanovic,Jorge H. Mestman,M. Hassan Murad,Yariv Yogev +6 more
TL;DR: Using an evidence-based approach, this Diabetes and Pregnancy Clinical Practice Guideline addresses important clinical issues in the contemporary management of women with type 1 or type 2 diabetes preconceptionally, during pregnancy, and in the postpartum setting.
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Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
TL;DR: The uses of metformin are analyzed not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.
References
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Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
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Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.
Sue Duval,Richard L. Tweedie +1 more
TL;DR: In this paper, a rank-based data augmentation technique is proposed for estimating the number of missing studies that might exist in a meta-analysis and the effect that these studies might have had on its outcome.
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Effects of Metformin on Early Pregnancy Loss in the Polycystic Ovary Syndrome
TL;DR: Metformin administration during pregnancy reduces first-trimester pregnancy loss in women with the polycystic ovary syndrome.
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Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone
David T. Vandermolen,Valerie S. Ratts,William S. Evans,Dale W Stovall,Scott W. Kauma,John E. Nestler +5 more
TL;DR: In anovulatory women with PCOS who are resistant to CC, metformin use significantly increased the ovulation rate and pregnancy rate from CC treatment.
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Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome
TL;DR: In PCOS, use of metformin is associated with a 10-fold reduction in gestational diabetes (31% to 3%).