Journal ArticleDOI
Preparation of alginate gel beads containing chitosan nicotinic acid salt and the functions.
TLDR
Calcium-induced alginate gel beads containing chitosan salt (Alg-CS) was prepared using nicotinic acid (NA), a drug for hyperlipidemia, and its two functions in gastrointestinal tract were investigated, finding an approximately linear relationship between them.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 1999-07-01. It has received 42 citations till now. The article focuses on the topics: Bile acid & Taurocholic acid.read more
Citations
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Journal ArticleDOI
Chitosan chemistry and pharmaceutical perspectives.
TL;DR: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. S. Nagar, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of medicine, Jerusalem 91120, Israel.
Journal ArticleDOI
Chitosan Nanoparticles: A Promising System in Novel Drug Delivery
TL;DR: The present review describes origin and properties of chitosan and its nanoparticles along with the different methods of its preparation and the various areas of novel drug delivery where it has got its application.
Chitosan nanoparticles: a promising system for drug delivery
TL;DR: The objectives of this review are to summarize the available preparation techniques involved chitosan nanoparticles, the application of explored chito-nanoparticles, and the mechanism of cell entry.
Journal ArticleDOI
Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres
Sinjan De,Dennis Robinson +1 more
TL;DR: Isothermal titration calorimetry studies determined that the primary binding affinity between calcium and alginate was 1.33 x 10(6)/mole and entropically driven, whereas, the second binding affinity was weaker and driven by both enthalpy and entropy and was competitively inhibited by sodium ions.
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Alginate/chitosan particulate systems for sodium diclofenac release
M.L. González-Rodríguez,Maria Angeles Holgado,C. Sanchez-Lafuente,Antonio M. Rabasco,Adamo Fini +4 more
TL;DR: The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium and the nature of the gelifying cation allow a control of the release rate of the drug.
References
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Journal ArticleDOI
Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery.
TL;DR: It was demonstrated that these new devices show promising potential for use in controlled delivery of drugs to the oral cavity by in situ crosslinking the chitosan with polycarbophil.
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Pulsed dextran release from calcium-alginate gel beads
TL;DR: The results indicate that pulsatile release of macromolecular drugs such as peptides and proteins could be achieved using calcium-alginate gel beads using mixing different bead sizes.
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The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan
TL;DR: The adherence of both coated and uncoated beads was much greater to the stomach mucosa than to oesophageal mucosa and the homogeneity of the alginate gel core influenced the adhesive properties with homogeneous capsules adhering better than the inhomogeneous capsules.
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Decreasing Effect of Chitosan on the Apparent Fat Digestibility by Rats Fed on a High-fat Diet
TL;DR: It is suggested that chitosan has potency for interfering with fat digestion and absorption in the intestinal tract, and for facilitating the excretion of dietary fat into the feces.
Journal ArticleDOI
Alternative approach to the preparation of chitosan beads
Cenk Aral,Jülide Akbuğa +1 more
TL;DR: In this paper, a controlled-release protein delivery system was investigated by using bovine serum albumin (BSA) as a model drug and spherical beads were produced with diameter in the range 0.78-0.92 mm and 13-90% encapsulation efficiency.