Journal ArticleDOI
Preparation of multiple unit hollow microspheres (microballoons) with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behavior (in vivo)
TLDR
In this paper, a multunit floating device for use in the stomach by the emulsion-solvent diffusion method was prepared by using tranilast, an oral anti-allergic agent, embedded in the shell of the microballoon.About:
This article is published in Journal of Controlled Release.The article was published on 1991-08-01. It has received 188 citations till now. The article focuses on the topics: Glass microsphere & Dosage form.read more
Citations
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Journal ArticleDOI
Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention
Brahma N. Singh,Kwon H. Kim +1 more
TL;DR: In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.
Journal ArticleDOI
Floating drug delivery systems: a review.
TL;DR: The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention.
Journal ArticleDOI
Gastroretentive drug delivery systems
TL;DR: An overview of the parameters affecting gastric emptying in humans as well as on the main concepts used to design pharmaceutical dosage forms with prolonged gastric residence times are given.
Journal ArticleDOI
Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery
TL;DR: The authors firstly review the literature dealing with drug absorption sites in the gastrointestinal tract, and descriptions are given of the methods used in determining the location of these sites, and the advantages and disavantages of each method are critically discussed.
Journal ArticleDOI
Drug delivery to the upper small intestine window using gastroretentive technologies
TL;DR: Approaches to achieving prolonged residence times of the devices in the upper part of the gastrointestinal tract include the use of bioadhesive, size-increasing, and floating drug delivery systems.
References
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Journal ArticleDOI
Solvent selection in the preparation of poly(dl-lactide) microspheres prepared by the solvent evaporation method
TL;DR: In this article, the authors used solvent evaporation to obtain poly( dl -lactide) microspheres containing quinidine or quinedinidine sulfate.
Journal ArticleDOI
The effect of density on the gastric emptying of single- and multiple-unit dosage forms
Stanley S. Davis,Anita F. Stockwell,Margaret J. Taylor,John G. Hardy,D. R. Whalley,Clive G. Wilson,Helle Bechgaard,Finn Norring Christensen +7 more
TL;DR: The presence of food in the stomach was found to be the major factor in determining the gastric emptying of single units and Floating or buoyant delivery systems may have little advantage over conventional systems.
Journal ArticleDOI
The Hydrodynamically Balanced System (Hbs™): A Novel Drug Delivery System for Oral Use
P. R. Sheth,J. Tossounian +1 more
TL;DR: Data on the gastric retentive characteristics of the HBS with diazepam and the mechanism of drug release for chlordiazepoxide from an HBS™ system are presented.
Journal ArticleDOI
A comparative study of the gastrointestinal transit of a pellet and tablet formulation
TL;DR: The transits of the formulations were found to be highly dependent on food intake and there was a good correlation between transit times (gastric emptying, arrival at colon) and the calorific value of the meal taken shortly before dosing.
Related Papers (5)
Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention
Brahma N. Singh,Kwon H. Kim +1 more