Floating drug delivery systems: a review.
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TLDR
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention.Abstract:
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.read more
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Disintegration of Solid Foods in Human Stomach
Fanbin Kong,R.P. Singh +1 more
TL;DR: A comprehensive review of food gastric digestion, focusing on disintegration of solid foods, is presented and is necessary to develop new guidelines for seeking innovative processing methods to manufacture foods specifically targeted for health.
Floating Drug Delivery Systems: A Review
TL;DR: In this review, current & recent developments of Stomach Specific FDDS are discussed and the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail.
Journal ArticleDOI
Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon
TL;DR: The manuscript considers strategies that are commonly used in practice for long-term administration of drugs, without interfering with human physiology, and feasible industrially for delivery by the oral route.
Journal ArticleDOI
Food, gastrointestinal pH, and models of oral drug absorption
TL;DR: Understanding of the physicochemical and physiological rate‐limiting factors affecting oral absorption, modellers can implement simplified population‐based modelling approaches that are less complex than whole‐body physiologically‐based models but still capture the essential elements in a physiological way and hence will be more suited for population modelling of large clinical data sets.
Journal ArticleDOI
Gastroretentive dosage forms: a review with special emphasis on floating drug delivery systems.
Vivek K. Pawar,Shaswat Kansal,Garima Garg,Rajendra Awasthi,Deepak Singodia,Giriraj T. Kulkarni +5 more
TL;DR: This review focused on the various aspects useful in development of GRDF including the current trends and advancements.
References
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Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention
Brahma N. Singh,Kwon H. Kim +1 more
TL;DR: In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.
Journal ArticleDOI
Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation
TL;DR: A model is proposed in which luminal H. pylori secrete substances that mediate inflammation that is beneficial to the organism but ultimately deleterious for the host; in addition to tissue damage, inflammation also affects gastric secretory function.
Journal ArticleDOI
Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract.
TL;DR: The present review focuses on the gastrointestinal bioadhesion of micro- and nanoparticles in the gastrointestinal tract, and proposes a strategy to associate drugs to polymeric nanoparticulate systems because of their propensity to interact with the mucosal surface.
Journal ArticleDOI
Development of a Novel Controlled-Release System for Gastric Retention
TL;DR: A novel controlled-release gastric retention system, which consists of a matrix tablet, coated with a permeable membrane, which should be greatly reduced due to tablet's expansion, and due to its disintegration or loss in integrity it should then be expelled out of the stomach at the end of the drug release.
Journal ArticleDOI
Gastroretentive drug delivery systems
TL;DR: An overview of the parameters affecting gastric emptying in humans as well as on the main concepts used to design pharmaceutical dosage forms with prolonged gastric residence times are given.
Related Papers (5)
Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention
Brahma N. Singh,Kwon H. Kim +1 more