Journal ArticleDOI
Prevalence and associated metabolic factors of fatty liver disease in the elderly.
Zhongli Wang,Ming Xu,Jianhong Peng,Li Jiang,Zhengguo Hu,Hua Wang,Shiqing Zhou,Rui Zhou,Michael Hultström,En Yin Lai +9 more
TLDR
The prevalence of FLD is higher in the elderly, and is broadly related to the same metabolic risk factors as in the non-elderly, however, female-sex is no longer protective with increasing age, and the prevalence of steatohepatitis with advanced fibrosis is estimated to be considerably higher inThe elderly FLD patients than in theNon-e Elderly FLD controls.About:
This article is published in Experimental Gerontology.The article was published on 2013-08-01. It has received 235 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Journal ArticleDOI
Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups
Amedeo Lonardo,Stefano Bellentani,Curtis K. Argo,Stefano Ballestri,Christopher D. Byrne,Stephen H. Caldwell,Helena Cortez-Pinto,Antonio Grieco,Mariana V. Machado,Luca Miele,Giovanni Targher +10 more
TL;DR: It is found that age, sex and ethnicity are major physiological modifiers of the risk of non-alcoholic fatty liver disease, along with belonging to "non- alcoholic fatty Liver disease families" and carrying risk alleles for selected genetic polymorphisms.
Journal ArticleDOI
NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk.
Stefano Ballestri,Fabio Nascimbeni,Enrica Baldelli,Alessandra Marrazzo,Dante Romagnoli,Amedeo Lonardo +5 more
TL;DR: Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma associated with striking systemic features and excess cardiovascular and liver-related mortality.
Journal ArticleDOI
Nonalcoholic fatty liver disease and aging: Epidemiology to management
Marco Bertolotti,Amedeo Lonardo,Chiara Mussi,Enrica Baldelli,E. Pellegrini,Stefano Ballestri,Dante Romagnoli,Paola Loria +7 more
TL;DR: The epidemiology and pathophysiology of this condition are reviewed, and a full discussion of the link between NAFLD and the aspects that are peculiar to elderly individuals is provided; these aspects include frailty, multimorbidity, polypharmacy and dementia.
Journal ArticleDOI
Sex-specific prevalence of fatty liver disease and associated metabolic factors in Wuhan, south central China.
TL;DR: The prevalence of FLD in China is high among men and elderly women and is mainly related to various metabolic parameters and age played a more prominent role in women.
Journal ArticleDOI
Economic and Quality-of-Life Implications of Non-Alcoholic Fatty Liver Disease
TL;DR: It is found that increased costs and decreased HR-QOL were associated with NAFLD.
References
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Journal ArticleDOI
Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
Brent A. Neuschwander-Tetri,Brent A. Neuschwander-Tetri,Stephen H. Caldwell,Stephen H. Caldwell +3 more
TL;DR: The research agenda for the future includes establishing the role of insulin resistance and abnormal lipoprotein metabolism in NASH, determining the pathogenesis of cellular injury, defining predisposing genetic abnormalities, identifying better noninvasive predictors of disease, and defining effective therapy.
Journal ArticleDOI
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Kitt Falk Petersen,Douglas E. Befroy,Sylvie Dufour,James Dziura,Charlotte E. Ariyan,Douglas L. Rothman,Loretta DiPietro,Gary W. Cline,Gerald I. Shulman +8 more
TL;DR: Elderly study participants were markedly insulin-resistant as compared with young controls, and this resistance was attributable to reduced insulin-stimulated muscle glucose metabolism, which supports the hypothesis that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly.
Journal ArticleDOI
Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
TL;DR: Older age, obesity, and presence of diabetes mellitus help identify those NASH patients who might have severe liver fibrosis, and this is the subgroup of patients who would be expected to derive the most benefit from having a liver biopsy and considering investigational therapies.
Journal ArticleDOI
Serum Uric Acid and Cardiovascular Mortality: The NHANES I Epidemiologic Follow-up Study, 1971-1992
Jing Fang,Michael H. Alderman +1 more
TL;DR: Increased serum uric acid levels had a positive relationship to cardiovascular mortality in men and women and in black and white persons and stratifying by cardiovascular risk status, diuretic use, and menopausal status confirmed this relationship.
Journal ArticleDOI
The prevalence and etiology of elevated aminotransferase levels in the United States.
TL;DR: Aminotransferase elevation was common in the United States, and the majority could not be unexplained by alcohol consumption, viral hepatitis or hemochromatosis, and thus may represent nonalcoholic fatty liver disease.
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