Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups
Amedeo Lonardo,Stefano Bellentani,Curtis K. Argo,Stefano Ballestri,Christopher D. Byrne,Stephen H. Caldwell,Helena Cortez-Pinto,Antonio Grieco,Mariana V. Machado,Luca Miele,Giovanni Targher +10 more
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TLDR
It is found that age, sex and ethnicity are major physiological modifiers of the risk of non-alcoholic fatty liver disease, along with belonging to "non- alcoholic fatty Liver disease families" and carrying risk alleles for selected genetic polymorphisms.About:
This article is published in Digestive and Liver Disease.The article was published on 2015-12-01 and is currently open access. It has received 357 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease & Fatty liver.read more
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Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis
TL;DR: Clinicians who manage patients with NAFLD should not focus only on liver disease but should also consider the increased risk of cardiovascular disease and undertake early, aggressive risk factor modification.
Journal ArticleDOI
Non-alcoholic fatty liver disease: An expanded review
Mark Benedict,Xuchen Zhang +1 more
TL;DR: The current knowledge of non-alcoholic fatty liver disease epidemiology, risk factors, diagnosis, pathogenesis, pathologic changes, natural history, and treatment is summarized to aid in further understanding this disease and better managing NAFLD patients.
Journal ArticleDOI
Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis.
Stefano Ballestri,Stefano Zona,Giovanni Targher,Dante Romagnoli,Enrica Baldelli,Fabio Nascimbeni,Alberto Roverato,Giovanni Guaraldi,Amedeo Lonardo +8 more
TL;DR: Patients with nonalcoholic fatty liver disease diagnosed by either serum liver enzymes (aminotransferases or gamma‐glutamyltransferase [GGT]) or ultrasonography are gauged for the risk of developing type 2 diabetes and metabolic syndrome.
Journal ArticleDOI
Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?
TL;DR: A rapidly expanding body of clinical evidence is critically discussed that supports the existence of a bi-directional relationship between NAFLD and various components of MetS, particularly T2DM and HTN, as well as the current knowledge regarding a strong association between NA FLD and CVD morbidity and mortality.
Journal ArticleDOI
Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis
TL;DR: NAFLD is significantly associated with a twofold increased risk of incident diabetes, however, the observational design of the eligible studies does not allow for proving causality.
References
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K. G. M. M. Alberti,Robert H. Eckel,Scott M. Grundy,Paul Zimmet,James I. Cleeman,Karen A. Donato,Jean Charles Fruchart,W. Philip T. James,Catherine M. Loria,Sidney C. Smith +9 more
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