Journal ArticleDOI
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
TLDR
Gut microflora might be a hitherto unexplored source of natural immunomodulators and probiotics, for prevention of atopic disease in children at high risk.About:
This article is published in The Lancet.The article was published on 2001-04-07. It has received 2429 citations till now. The article focuses on the topics: Asthma & Hygiene hypothesis.read more
Citations
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Journal ArticleDOI
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.
E. Joanna Baxter,Linda M. Scott,Peter J. Campbell,Clare L. East,Nasios Fourouclas,Soheila Swanton,George S. Vassiliou,Anthony J. Bench,Elaine M. Boyd,Natasha Curtin,Michael A. Scott,Wendy N. Erber,Anthony R. Green,Anthony R. Green +13 more
TL;DR: A single acquired mutation of JAK2 was noted in more than half of patients with a myeloproliferative disorder and its presence in all erythropoietin-independent erythroid colonies demonstrates a link with growth factor hypersensitivity, a key biological feature of these disorders.
Journal ArticleDOI
Gut flora in health and disease
TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.
Journal ArticleDOI
Gut Microbiota in Health and Disease
TL;DR: The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.
Journal ArticleDOI
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
TL;DR: This review examines the evidence in support of the hygiene hypothesis and offers a number of mechanisms that could explain the relation between sanitary conditions and susceptibility to allergic and autoimmune diseases.
References
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Journal ArticleDOI
Hay fever, hygiene, and household size.
TL;DR: A possible explanation forHay fever trends over time is suggested, as well as a recent increase in the prevalence of asthma2 and childhood eczema.
Journal ArticleDOI
Probiotics in man and animals
TL;DR: In this paper, the authors used probiotic treatments to re-establish the natural condition which exists in the wild animal but which has been disrupted by modern trends in conditions used for rearing young animals, including human babies, and in modern approaches to nutrition and disease therapy.
Journal ArticleDOI
Asthma and wheezing in the first six years of life. The Group Health Medical Associates.
Fernando D. Martinez,Anne L. Wright,Lynn M. Taussig,Catharine J. Holberg,Marilyn Halonen,Wayne J. Morgan +5 more
TL;DR: Children who started wheezing in early life and continued to wheeze at the age of six were more likely than the children who never wheezed to have mothers with a history of asthma, but do not have increased risks of asthma or allergies later in life.
Journal Article
Probiotics in man and animals
TL;DR: These are all areas where the gut flora can be altered for the worse and where, by the administration of probiotics, the natural balance of the gut microflora can be restored and the animal returned to its normal nutrition, growth and health status.
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Heli Majamaa,Erika Isolauri +1 more