scispace - formally typeset
Book ChapterDOI

Problems and Approaches

Felipe Fernández-Armesto
- pp 1-8
TLDR
A few years ago, an advertising campaign of the Greek national tourist authority strewed the pages of glossy magazines with pictures of nubile tourists cavorting amid Doric ruins over the slogan, "You were born in Greece".
Abstract
A few years ago, an advertising campaign of the Greek national tourist authority strewed the pages of glossy magazines with pictures of nubile tourists cavorting amid Doric ruins over the slogan, ‘You were born in Greece’. Taken literally, the words would have been obscure. Yet no reader can have had any difficulty in interpreting them as an allusion to the doctrine that ‘western society’ derives, by unbroken tradition, from Graeco-Roman origins. The doctrine may not be true; the terms in which it is commonly expressed may be misleading. Yet its influence is such that it forms part of the self-perception of almost every educated person in Europe and the Americas and much of the rest of the world today. Studies of periods of crisis in the transmission of the supposed legacy – in late antiquity or the early middle ages, when rival cultural traditions were received, or in the ‘age of expansion’ when western society is thought to have broken out of its heartlands – have concentrated, like Theseus in the labyrinth, on following as if it were a lifeline this single, tenuous thread.

read more

Citations
More filters
Journal ArticleDOI

Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

TL;DR: The evidence for reduced penetrance being a widespread phenomenon in human genetics is summarized and some of the molecular mechanisms that may help to explain this enigmatic characteristic of human inherited disease are explored.
Journal ArticleDOI

The Molecular Descent of the Major Histocompatibility Complex

TL;DR: The Mhc genes are found to evolve at a relatively slow rate with the regularity of a clock and the nonsynonymous sites coding for the peptide-binding region (PBR) are under moderate negative selection pressure.
Journal ArticleDOI

De novo expansion of a (CAG)n repeat in sporadic Huntington's disease.

TL;DR: Nine families with potential de novo expression of Huntington's disease are examined, finding elderly unaffected relatives inherited the same chromosome as that containing the expanded repeat in the proband, but had repeat lengths of 34–38 units, spanning the gap between the normal and HD distributions.
Journal ArticleDOI

Informativity assessment for biallelic single nucleotide polymorphisms

TL;DR: The number N, the equivalent number of maximally informative SNPs, is suggested as a measure of marker informativity in the context of kinship testing because Linear regression analysis of a large number of simulated SNP sets reveals that only a minor linear correction of N is required for large n.