Journal ArticleDOI
Procaine inhibition of fibroblast motility and proliferation.
M.H. Gail,Ch.W. Boone +1 more
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Pharmacologic doses of procaine reversibly inhibit fibroblast motility and cell proliferation and these findings are discussed with reference to recent studies on cell membrane potential.About:
This article is published in Experimental Cell Research.The article was published on 1972-07-01. It has received 55 citations till now. The article focuses on the topics: Motility & Cell growth.read more
Citations
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Journal ArticleDOI
Transmembrane control of the receptors on normal and tumor cells: I. Cytoplasmic influence over cell surface components☆
Journal ArticleDOI
Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.
TL;DR: Ca2+-activated, phospholipid-dependent protein kinase recently found in mammalian tissues is inhibited by various phospholIPid-interacting drugs such as chlorpromazine, imipramine, phentolamine, dibucaine, verapamil, and tetracaine but a catalytic fragment of this enzyme, obtained by limited proteolysis with Ca2-dependent neutral protease, is fully active and not susceptible to any of these drugs.
Book ChapterDOI
Membrane and Cytoplasmic Changes in B Lymphocytes Induced by Ligand-Surface Immunoglobulin Interaction
TL;DR: This chapter discusses membrane and cytoplasmic changes in B lymphocytes induced by ligand–surface immunoglobulin (Ig) interaction by using ultrastructural analysis of regular thin section of cells exposed to antibodies conjugated to a large visible molecule.
Journal ArticleDOI
Effects of local anesthetics on cell morphology and membrane-associated cytoskeletal organization in BALB/3T3 cells.
TL;DR: The relationship of the findings on local anesthetic-induced changes in cellular cytoskeletal systems is discussed in relation to previous proposals on plasma membrane organization and control of cell surface receptor topography and mobility.
Journal ArticleDOI
Local anesthetics affect transmembrane cytoskeletal control of mobility and distribution of cell surface receptors.
TL;DR: Evidence supports the proposal that anesthetics affect the organization of cytoskeletal components or their plasma membrane attachment points by the participation of membrane-associated microtubules and microfilaments in the transmembrane control of receptor mobility.
References
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Journal ArticleDOI
The locomotion of fibroblasts in culture I. Movements of the leading edge
TL;DR: During the locomotion on a plane surface of fibroblast-like cells from embryonic chick heart and neonatal mouse muscle, any point on the leading edge undergoes a repetitive protrusion and withdrawal, covering about 5 μm which is quantitatively very similar in the two kinds of cell.
Journal ArticleDOI
The Locomotion of Mouse Fibroblasts in Tissue Culture
TL;DR: A random walk model, modified to comprehend the persistence effect, was found to describe the motion of fibroblasts in tissue culture and to provide a numerical measure of cellular motility.
Journal ArticleDOI
Effect of procaine on electrical properties of squid axon membrane.
TL;DR: Procaine (0.025–0.1%; pH 7.9) caused a reduction in the amount and rate of development of the early transient and late steady state currents which occur during a depolarizing voltage step applied to the excised, voltage clamped squid axon.
Journal ArticleDOI
Cell-substrate adhesivity. A determinant of cell motility.
M.H. Gail,Ch.W. Boone +1 more
TL;DR: In the situations studied, increased adhesivity was associated with decreased motility for both 3T3 fibroblasts and SV3T3 viral transformants, suggesting that cell motility depends on cell-substrate adhesivities.
Journal ArticleDOI
Control of Somatic Cell Mitosis by Simulated Changes in the Transmembrane Potential Level
C.D. Cone,M. Tongier +1 more
TL;DR: Experiments designed to test the premis that variations in intracellular ionic concentrations accompanying different levels of the electrical transmembrane potential difference might serve as a mechanistic difference.