Journal ArticleDOI
Prognostic impact of circulating monocytes and lymphocyte-to-monocyte ratio on previously untreated metastatic non-small cell lung cancer patients receiving platinum-based doublet
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TLDR
It is implicate that circulating AMC and LMR are regarded as independent prognostic factors for PFS and OS in previously untreated metastatic NSCLC patients receiving platinum-based doublet.Abstract:
The link between circulating lymphocyte-to-monocyte ratio (LMR) and newly diagnosed metastatic non-small cell lung cancer (NSCLC) is not fully defined. The study was conducted to evaluate the prognostic impact of LMR on survival outcomes in previously untreated metastatic NSCLC patients receiving platinum-based doublet. Chemotherapy-naive metastatic NSCLC patients undergoing platinum-based doublet were retrospectively enrolled. Clinical features regarding gender, age, Eastern Cooperative Oncology Group (ECOG) performance status, histology, absolute lymphocyte count (ALC), absolute monocyte count (AMC) and LMR were collected to determinate their prognostic impact on progression-free survival (PFS) and overall survival (OS). Up to 370 patients were eligible for the study. By univariate analysis, ECOG performance status, histology, ALC, AMC and LMR were showed to be significantly associated with PFS and OS. In subsequent Cox multivariate analysis, non-squamous cell carcinoma, ALC ≥ 2.45 × 10(9)/L, AMC <0.45 × 10(9)/L and LMR ≥ 4.56 were demonstrated to be independently correlated with better PFS. In addition, independent favorable prognostic factors for OS were only limited to LMR ≥ 4.56 and non-squamous cell carcinoma, whereas ECOG performance status of 2 and AMC ≥ 0.45 × 10(9)/L remained as independently inferior prognostic indicators for OS. Our findings implicate that circulating AMC and LMR are regarded as independent prognostic factors for PFS and OS in previously untreated metastatic NSCLC patients receiving platinum-based doublet.read more
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Journal ArticleDOI
Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: A systematic review and meta-analysis
TL;DR: A low pre-treatment LMR seems to represent an unfavorable and robust prognostic factor for clinical outcomes in patients with non-hematologic malignancies.
Journal ArticleDOI
Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI).
TL;DR: High NLR, high PLR, low LMR and low ALI at baseline and post first cycle of treatment are significantly associated with poor OS post treatment and similar prognostic trends were noted for elderly.
Journal ArticleDOI
Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis.
Liangyou Gu,Hongzhao Li,Luyao Chen,Xin Ma,Xintao Li,Yu Gao,Yu Zhang,Yongpeng Xie,Yongpeng Xie,Xu Zhang +9 more
TL;DR: It is concluded that a decreased LMR implied poor prognosis in patients with cancer and could serve as a readily available and inexpensive biomarker for clinical decision.
Journal ArticleDOI
The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer.
Wan Kyu Eo,Hyejung Chang,Sang Hoon Kwon,Suk Bong Koh,Young Ok Kim,Yong Il Ji,Hong-Bae Kim,Ji Young Lee,Dong Soo Suh,Ki Hyung Kim,Ik Jin Chang,Heung Yeol Kim,Suk Choo Chang +12 more
TL;DR: The LMR is an independent prognostic factor affecting the survival of patients with EOC and is validated as an independent predictor of survival.
Journal ArticleDOI
An inflammatory biomarker-based nomogram to predict prognosis of patients with nasopharyngeal carcinoma: an analysis of a prospective study.
Xiaohui Li,Hui Chang,Bing Qing Xu,Ya Lan Tao,Jin Gao,Chen Chen,Chen Qu,Shu Zhou,Song Ran Liu,Xiaohui Wang,Wen Wen Zhang,Xin Yang,Si Lang Zhou,Yun Fei Xia +13 more
TL;DR: The aim of this analysis was to evaluate whether inflammatory biomarkers such as the Glasgow prognostic score (GPS), the neutrophil‐lymphocyte ratio (NLR), the platelet-lymphocytes ratio (PLR), and the lymphocyte‐monocyte ratios (LMR) could predict the prognosis of nasopharyngeal carcinoma (NPC).
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