Journal ArticleDOI
Prognostic value of serum uric acid: new-onset in and out-of-office hypertension and long-term mortality.
Michele Bombelli,I. Ronchi,Marco Volpe,Rita Facchetti,Stefano Carugo,Raffaella Dell'Oro,Cesare Cuspidi,Guido Grassi,Giuseppe Mancia +8 more
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TLDR
In the general population of the Pressioni Arteriose Monitorate E Loro Associazioni study, SUA correlated with a number of cardiovascular risk factors but independently predicts new-onset out-of-office hypertension, and long-term cardiovascular and all-cause mortality.Abstract:
Objective Serum uric acid (SUA) has been associated with an increased cardiovascular risk, but no conclusive evidence exists on whether it is an independent risk factor or a reflection of other risk factors to which it is related. We examined the relationship of SUA with a number of cardiovascular variables [including risk factors never evaluated before, such as organ damage and out-of-office blood pressure (BP)], as well as its prognostic relevance in the population. Methods In 2045 participants of the Pressioni Arteriose Monitorate E Loro Associazioni study, we measured, along with SUA, metabolic, renal, and anthropometric variables, left-ventricular mass index, and office, home and ambulatory BP. Cardiovascular and all-cause mortality was assessed over a 16-year follow-up period, and measurements were repeated 10 years after the initial data collection. Results Baseline SUA had a near-normal distribution, with a mean value of 4.9 ± 1.3 (SD) mg/dl and a significant direct relationship with BP and metabolic variables, serum creatinine and left-ventricular mass index. It was among the factors independently predicting new-onset home and ambulatory hypertension, the increased risk of developing these conditions for 1 mg/dl increase of SUA after adjustment for all available potential confounders being 34 and 29%, respectively (P = 0.015 and P = 0.014). An increase in SUA of 1 mg/dl also independently predicted cardiovascular and all-cause mortality, the fully adjusted increase in risk being 22% (P = 0.03) and 12% (P = 0.04), respectively. Conclusion In the general population of the Pressioni Arteriose Monitorate E Loro Associazioni study, SUA correlated with a number of cardiovascular risk factors. Nevertheless, it independently predicts new-onset out-of-office hypertension, and long-term cardiovascular and all-cause mortality.read more
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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Satoshi Umemura,Hisatomi Arima,Shuji Arima,Kei Asayama,Yasuaki Dohi,Yoshitaka Hirooka,Takeshi Horio,Satoshi Hoshide,Shunya Ikeda,Toshihiko Ishimitsu,Masaaki Ito,Sadayoshi Ito,Yoshio Iwashima,Hisashi Kai,Kei Kamide,Yoshihiko Kanno,Naoki Kashihara,Yuhei Kawano,Toru Kikuchi,Kazuo Kitamura,Takanari Kitazono,Katsuhiko Kohara,Masataka Kudo,Hiroo Kumagai,Kiyoshi Matsumura,Hideo Matsuura,Katsuyuki Miura,Masashi Mukoyama,Satoko Nakamura,Takayoshi Ohkubo,Yusuke Ohya,Takafumi Okura,Hiromi Rakugi,Shigeyuki Saitoh,Hirotaka Shibata,Tatsuo Shimosawa,Hiromichi Suzuki,Shori Takahashi,Kouichi Tamura,Hirofumi Tomiyama,Takuya Tsuchihashi,Shinichiro Ueda,Yoshinari Uehara,Hidenori Urata,Nobuhito Hirawa +44 more
TL;DR: The story of the life and times of Toshihiko Umemura and his family in the years leading up to and including his death.
Journal ArticleDOI
Serum uric acid and the risk of cardiovascular and renal disease.
Claudio Borghi,Enrico Agabiti Rosei,Thomas Bardin,Jesse Dawson,Anna F. Dominiczak,Jan T. Kielstein,Athanasios J. Manolis,Fernando Perez-Ruiz,Giuseppe Mancia +8 more
TL;DR: The demonstrated efficacy of urate-lowering therapy on outcomes other than gout flares leads to the consideration that treatment may be beneficial even in the absence of overt gout when hyperuricemia accompanies other clinical conditions, such as urate deposition, advanced CKD or cardiovascular risk factors.
Journal ArticleDOI
Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study.
TL;DR: A high level of uric acid indicated a higher likelihood of developing hypertension in both genders and metabolic syndrome in males after 10 years of follow-up, however, uric Acid levels did not affect the occurrence of type 2 diabetes in both sexes.
Journal ArticleDOI
Uric Acid and Cardiovascular Disease: An Update.
TL;DR: In this article, the authors show that patients with hyperuricaemia SUA are at increased risk of cardiac, renal and vascular damage and CV events, and they suggest that urate-lowering treatment may reduce CV risk in this group and, thus, may represent a new strategy in risk reduction.
References
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Journal ArticleDOI
2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
Giuseppe Mancia,Robert Fagard,Krzysztof Narkiewicz,Josep Redon,Alberto Zanchetti,Michael Böhm,Thierry Christiaens,Renata Cifkova,Guy De Backer,Anna Dominiczak,Maurizio Galderisi,Diederick E. Grobbee,Tiny Jaarsma,Paulus Kirchhof,Sverre E. Kjeldsen,Stephane Laurent,Athanasios J. Manolis,Peter M. Nilsson,Luis M. Ruilope,Roland E. Schmieder,Per Anton Sirnes,Peter Sleight,Margus Viigimaa,Bernard Waeber,Faiez Zannad +24 more
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Journal ArticleDOI
Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.
Richard B. Devereux,N Reichek +1 more
TL;DR: The best method for LVM-E identified combined cube function geometry with a modified convention for determination of left ventricular internal dimension (LVID), posterior wall thickness (PWT), and interventricular septal thickness (IVST), which excluded the thickness of endocardial echo lines from wall thicknesses and included the thickness in LVID.
Journal ArticleDOI
Serum Uric Acid and Cardiovascular Mortality: The NHANES I Epidemiologic Follow-up Study, 1971-1992
Jing Fang,Michael H. Alderman +1 more
TL;DR: Increased serum uric acid levels had a positive relationship to cardiovascular mortality in men and women and in black and white persons and stratifying by cardiovascular risk status, diuretic use, and menopausal status confirmed this relationship.
Journal ArticleDOI
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Marilda Mazzali,Jeremy Hughes,Yoon Goo Kim,J. Ashley Jefferson,Duk Hee Kang,Katherine L. Gordon,Hui Y. Lan,Salah D. Kivlighn,Richard J. Johnson +8 more
TL;DR: Mild hyperuricemia causes hypertension and renal injury in the rat via a crystal-independent mechanism, with stimulation of the renin-angiotensin system and inhibition of neuronal NO synthase.
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