Journal ArticleDOI
Progress in the construction of cyclooctanoid systems: new approaches and applications to natural product syntheses.
About:
This article is published in Chemical Reviews.The article was published on 1999-02-20. It has received 259 citations till now.read more
Citations
More filters
Journal ArticleDOI
Transition-metal-catalyzed enantioselective [2+2+2] cycloadditions for the synthesis of axially chiral biaryls.
TL;DR: The enantioselective synthesis of axially chiral biaryls possessing non-biaryl axial chirality was also developed by using chiral rhodium(I) complexes as catalysts.
Journal ArticleDOI
Asymmetric synthesis of medium-sized rings by intramolecular Au(I)-catalyzed cyclopropanation.
TL;DR: The results provide insight into the mechanism, showing the fluxional nature of gold(I)-stabilized vinyl carbenoid intermediates, and high enantioselectivities can be achieved for 7- and 8-membered ring products employing chiralGold(I) complexes.
Journal ArticleDOI
Dienamine Catalysis: An Emerging Technology in Organic Synthesis
TL;DR: The entire saga of dienamine chemistry from “preformed dienamines” to “in situ dienines” and its applications in the synthesis of bioactive molecules and natural products are discussed.
Journal ArticleDOI
New reactions and step economy: the total synthesis of (±)-salsolene oxide based on the type II transition metal-catalyzed intramolecular [4 + 4] cycloaddition
TL;DR: In this paper, the viability of the type II nickel-catalyzed intramolecular [4+4] cycloaddition of bis-dienes was investigated. But the results were limited.
Journal ArticleDOI
Selective construction of carbocyclic eight-membered rings by ring-closing metathesis of acyclic precursors.
Antoine Michaut,Jean Rodriguez +1 more
TL;DR: This Minireview describes the utilization of ring-closing metathesis (RCM) as a new approach to synthesize cyclooctanoids.
References
More filters
Journal ArticleDOI
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Journal ArticleDOI
Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way
TL;DR: The ability of transition metal complexes to preorganize π-electron systems serves as the basis both of simple additions usually accompanied by subsequent hydrogen shifts and of cycloadditions as mentioned in this paper.
Journal ArticleDOI
Transition Metal-Mediated Cycloaddition Reactions
TL;DR: The phytochemical remains of the seven-membered ring formation are still under investigation, but it is clear that the polymethine content of the ring is lower than previously thought, suggesting that it is more likely to be a mixture of 22π and 32σ.
Journal ArticleDOI
Total synthesis of taxol
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Zhen Yang,J. J. Liu,H. Ueno,P. G. Nantermet,R. K. Guy,Christopher F. Claiborne,J. Renaud,Elias A. Couladouros,K. Paulvannan,Erik J. Sorensen,Erik J. Sorensen +12 more
TL;DR: The total synthesis of taxol is reported by a convergent strategy, which opens a chemical pathway for the production of both the natural product itself and a variety of designed taxoids.
Journal ArticleDOI
Ring-Closing Metathesis and Related Processes in Organic Synthesis
TL;DR: The transition metal alkylidene-catalyzed olefin metathesis reaction and the related transition metal-mediated carbonyl olefination reaction are two such processes as discussed by the authors.