Journal ArticleDOI
Progress in the mitsunobu reaction. a review
TLDR
A review of progress in the MITSUNOBU this article reaction can be found in this article, with a focus on the MIT SUNOBU reaction and a review of the progress.About:
This article is published in Organic Preparations and Procedures International.The article was published on 1996-04-01. It has received 373 citations till now. The article focuses on the topics: Mitsunobu reaction.read more
Citations
More filters
Patent
Pharmaceutical compositions and methods for effecting dopamine release
TL;DR: In this paper, a 1-aza-2-(3-pyridyl) bicyclo is used to treat central nervous system disorders such as Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia.
Journal ArticleDOI
Mitsunobu Reaction Using Basic Amines as Pronucleophiles.
Hai Huang,Jun Yong Kang +1 more
TL;DR: A novel protocol for extending the scope of the Mitsunobu reaction to include amine nucleophiles to form C-N bonds through the utilization of N-heterocyclic phosphine-butane (NHP- butane) has been developed.
Journal ArticleDOI
An access to 3,4-(aminomethano)proline in racemic and enantiomerically pure form.
TL;DR: In this paper, a titanium-mediated reductive cyclopropanation of N,N-dibenzylformamide with titanacyclopropanes generated in situ from racemic or enantiomerically pure tert-butyl N-Boc-3,4-dehydroprolinates rac-8 or (S)-8 proceed diastereoselectively.
Patent
1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive mglur2-receptor modulators
José Maria Cid-Núñez,Andrés Avelino Trabanco-Suárez,Gregor James Macdonald,Guillaume Albert Jacques Duvey,Robert Johannes Lütjens +4 more
TL;DR: In this paper, positive allosteric modulators of metabotropic glutamate receptors subtype 2 ("mGluR2") are used for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGlu receptor is involved.
Journal ArticleDOI
Enantiopure chiral (2,4,6-triisopropylbenzoyl)oxy-[D1]methyllithium: configurational stability, reactions, and mechanistic studies.
TL;DR: The configurational stability of enantiopure chiral (2,4,6-triisopropylbenzoyl)oxy-[D(1)]methyllithium generated by a tin-lithium exchange was tested on the macroscopic time scale, employing trapping experiments with benzaldehyde.
References
More filters
Journal ArticleDOI
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
Journal ArticleDOI
Conformational analysis—CI
TL;DR: In this paper, it was concluded that the gauche-butane interaction has been incorrectly interpreted as to origin, and that the relationship between methyl groups is not the cause of the relative instability of gauche conformations.
Journal ArticleDOI
Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts
Oyo Mitsunobu,Masaaki Yamada +1 more
TL;DR: In this article, the reaction of carboxylic acid with triphenyl phosphine and diethyl azodicarboxylate in the presence of an alcohol has been studied.
Journal ArticleDOI
Efficacious modification of the mitsunobu reaction for inversions of sterically hindered secondary alcohols
TL;DR: In this article, a modification of the Mitsunobu protocol for effecting stereochemical inversions of alcohols has been discovered in which use of p-nitrobenzoic acid as the nucleophilic partner results in significantly improved yields with relatively hindered substrates.
Journal ArticleDOI
Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to mitsunobu conditions
TL;DR: In this article, 14 alcohols were converted to their corresponding azides with inversion of configuration using diphenyl phosphorazidate and DBU, and the resulting azides were converted into azides.
Related Papers (5)
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts
Oyo Mitsunobu,Masaaki Yamada +1 more