Journal ArticleDOI
Progress in the mitsunobu reaction. a review
TLDR
A review of progress in the MITSUNOBU this article reaction can be found in this article, with a focus on the MIT SUNOBU reaction and a review of the progress.About:
This article is published in Organic Preparations and Procedures International.The article was published on 1996-04-01. It has received 373 citations till now. The article focuses on the topics: Mitsunobu reaction.read more
Citations
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Synthesis of a high-affinity Fluorescent PPARγ ligand for high-throughput fluorescence polarization assays
TL;DR: This fluorescent PPARgamma probe enables high-throughput and homogenous FP assays for the identification of novel endogenous and exogenous PPargamma ligands, and this rational ligand design approach may be applied to other therapeutically important members of the nuclear hormone receptor superfamily.
Journal ArticleDOI
Enantioselective Synthesis of the AB-Ring System of the Antitumor Antibiotic Tetrazomine
Peter Wipf,Corey R. Hopkins +1 more
TL;DR: The synthesis of the 1,2,3,4-tetrahydroisoquinoline moiety of tetrazomine was accomplished in 18 steps and in 3% overall yield from commercially available o-anisaldehyde.
Journal ArticleDOI
Inotropic activity of hydroindene amidinohydrazones.
Luis Garcia Sevillano,C. P. Melero,E. Caballero,F. Tome,L. G. Lelievre,Käthi Geering,Gilles Crambert,Rosalía Carrón,M. Medarde,Arturo San Feliciano +9 more
TL;DR: Both active compounds act without affecting the cardiac rhythm, and could be related to the selective inhibition of the human alpha2beta1 isozyme with respect to the alpha1beta1isozyme.
Journal ArticleDOI
Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes
TL;DR: The development of the first redox-free protocol for the Mitsunobu reaction is described, achieved by exploiting triphenylphosphine oxide--the unwanted by-product in the conventional Mitsun Obu reaction--as the precursor to the active P(V) coupling reagent.
Journal ArticleDOI
Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties.
Ronald Palin,Anton Bom,John K. Clark,Louise Evans,Helen Feilden,Andrea K. Houghton,Philip S. Jones,Brian Montgomery,Mark A. Weston,Grant Wishart +9 more
TL;DR: The N-methyl acetamide derivative (+)-7f was found to be a high-affinity, potent NOP agonist with greater than 100-fold selectivity over the MOP receptor.
References
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Journal ArticleDOI
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
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Conformational analysis—CI
TL;DR: In this paper, it was concluded that the gauche-butane interaction has been incorrectly interpreted as to origin, and that the relationship between methyl groups is not the cause of the relative instability of gauche conformations.
Journal ArticleDOI
Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts
Oyo Mitsunobu,Masaaki Yamada +1 more
TL;DR: In this article, the reaction of carboxylic acid with triphenyl phosphine and diethyl azodicarboxylate in the presence of an alcohol has been studied.
Journal ArticleDOI
Efficacious modification of the mitsunobu reaction for inversions of sterically hindered secondary alcohols
TL;DR: In this article, a modification of the Mitsunobu protocol for effecting stereochemical inversions of alcohols has been discovered in which use of p-nitrobenzoic acid as the nucleophilic partner results in significantly improved yields with relatively hindered substrates.
Journal ArticleDOI
Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to mitsunobu conditions
TL;DR: In this article, 14 alcohols were converted to their corresponding azides with inversion of configuration using diphenyl phosphorazidate and DBU, and the resulting azides were converted into azides.
Related Papers (5)
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts
Oyo Mitsunobu,Masaaki Yamada +1 more