Journal ArticleDOI
Progress in the mitsunobu reaction. a review
TLDR
A review of progress in the MITSUNOBU this article reaction can be found in this article, with a focus on the MIT SUNOBU reaction and a review of the progress.About:
This article is published in Organic Preparations and Procedures International.The article was published on 1996-04-01. It has received 373 citations till now. The article focuses on the topics: Mitsunobu reaction.read more
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Reference EntryDOI
1,2,4‐Dithiazolidine‐3,5‐dione
TL;DR: In this paper, the authors used anhydrous diethyl ether to give the optimum yield, while also minimizing the formation of unwanted by-products in the storage of primary amines.
Patent
1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of neurological and psychiatric disorders
Cid-Nunez Jose Maria,Daniel Oehlrich,Andrés Avelino Trabanco-Suárez,Gary Tresadern,Vega Ramiro Juan Antonio,Macdonald Gregor James +5 more
TL;DR: In this paper, a triazolo[4,3-a]pyridine derivatives of Formula (I) were used for the treatment of neurological disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved.
Patent
Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of mGluR2 receptors
Sergio-Alvar Alonso-De Diego,José Maria Cid-Núñez,Óscar Delgado-González,Annelies Marie Antonius Decorte,Michiel Van Gool,Gregor James Macdonald,Antonius Adrianus Hendrikus Petrus Megens,Andrés Avelino Trabanco-Suárez,Aránzazu García-Molina,Jose Ignacio Andres-Gil +9 more
TL;DR: In this article, the 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of Formula (I) are used as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (mGluR2).
Journal ArticleDOI
Recent advances in the synthesis of 4'-truncated nucleoside phosphonic acid analogues.
Guang Huan Shen,Joon Hee Hong +1 more
TL;DR: In this paper , the synthesis of four series of 4-truncated nucleoside phosphonic acid analogues is discussed, and their biological activity results are briefly discussed; see Section 2.1.
Book ChapterDOI
Addition of hydrocyanic acid to carbonyl compounds
TL;DR: The hydroxynitrile lyase (HNL)-catalyzed addition of HCN to aldehydes is the most important synthesis of non-racemic cyanohydrins as mentioned in this paper.
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The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
Journal ArticleDOI
Conformational analysis—CI
TL;DR: In this paper, it was concluded that the gauche-butane interaction has been incorrectly interpreted as to origin, and that the relationship between methyl groups is not the cause of the relative instability of gauche conformations.
Journal ArticleDOI
Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts
Oyo Mitsunobu,Masaaki Yamada +1 more
TL;DR: In this article, the reaction of carboxylic acid with triphenyl phosphine and diethyl azodicarboxylate in the presence of an alcohol has been studied.
Journal ArticleDOI
Efficacious modification of the mitsunobu reaction for inversions of sterically hindered secondary alcohols
TL;DR: In this article, a modification of the Mitsunobu protocol for effecting stereochemical inversions of alcohols has been discovered in which use of p-nitrobenzoic acid as the nucleophilic partner results in significantly improved yields with relatively hindered substrates.
Journal ArticleDOI
Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to mitsunobu conditions
TL;DR: In this article, 14 alcohols were converted to their corresponding azides with inversion of configuration using diphenyl phosphorazidate and DBU, and the resulting azides were converted into azides.
Related Papers (5)
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts
Oyo Mitsunobu,Masaaki Yamada +1 more