Properties and applications of protein-stabilized fluorescent gold nanoclusters: short review
TLDR
In this paper, the strategy for synthesizing fluorescent protein-gold nanoclusters and the characterization methods employed to study these systems are discussed, as well as the promising future for fluorescent protein and gold nanomaterials as long as research continues to uncover fundamental structure-property relation ships.Abstract:
Research is turning toward nanotechnology for solutions to current limitations in bio- medical imaging and analytical detection applications. New to fluorescent nanomaterials that could help advance such applications are protein-stabilized gold nanoclusters. They are potential candidates for imaging agents and sensitive fluorescence sensors because of their biocompat- ibility and intense photoluminescence. This review discusses the strategy for synthesizing fluorescent protein-gold nanoclusters and the characterization methods employed to study these systems. Optical properties and relevant light-emitting applications are reported to present the versatility of protein-gold nanoclusters. These new bio-nano hybrids are an exciting new system that remains to be explored in many aspects, especially regarding the determination of gold nanocluster local structure and the enhancement of quantum yields. Understanding how to finely tune the optical properties will be pivotal for improving fluorescence imaging and other nanocluster applications. There is a promising future for fluorescent protein-gold nanoclusters as long as research continues to uncover fundamental structure-property relation- ships. © 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). (DOI: 10.1117/1.JNP.6read more
Citations
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Engineering ultrasmall water-soluble gold and silver nanoclusters for biomedical applications
TL;DR: It is believed that with continued efforts to understand the interactions of biomolecule-protected Au/ Ag NCs with the biological systems, scientists can largely realize the great potential of Au/Ag NCs for biomedical applications, which could finally pave their way towards clinical use.
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Noble Metal Clusters: Applications in Energy, Environment, and Biology
Ammu Mathew,Thalappil Pradeep +1 more
TL;DR: Sub-nanometer-sized metal clusters, having dimensions between metal atoms and nanoparticles, have attracted tremendous attention in the recent past due to their unique physical and chemical properties. as discussed by the authors provides an account of the recent advances in their applications in areas such as environment, energy, and biology.
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Luminescent Noble Metal Nanoclusters as an Emerging Optical Probe for Sensor Development
TL;DR: This Focus Review briefly summarizes the common syntheses for water-soluble highly-luminescent thiolate- and protein-protected Au/Ag NCs and their interesting luminescence properties, highlights recent progress in their use as optical sensors with an emphasis on the mechanisms underlying their selectivity, and discusses approaches to improving their sensitivity.
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Lighting up thiolated Au@Ag nanoclusters via aggregation-induced emission
TL;DR: A simple strategy has been developed to synthesize highly luminescent thiolate Au@Ag nanoclusters (NCs) by using Ag(i) ions to bridge small Au(i)-thiolate motifs on the weakly luminescence thiolated Au NCs, leading to the formation of large Au( i)/Ag(i-thiolates on the NC surface and thus generating strong Luminescence via aggregation-induced emission.
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Fluorescent Gold Nanoclusters for Selective Detection of Dopamine in Cerebrospinal fluid.
TL;DR: Stable, nontoxic and red fluorescent emission BSA-Au NCs for selective detection of L-dopamine (DA) in cerebrospinal fluid (CSF) and as-prepared BSA -AuNCs will gain possible strategy and good platform for biosensor, drug discovery, and rapid disease diagnosis such as Parkinson’s and Alzheimer diseases.
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